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Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexesFunctional organization of the Sm core in the crystal structure of human U1 snRNPProtein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometryStructure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopyMolecular architecture of the human U4/U6.U5 tri-snRNPMolecular architecture of the Saccharomyces cerevisiae activated spliceosomeLocalization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy.Discriminatory RNP remodeling by the DEAD-box protein DED1.Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexesOrganization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy.The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.ATPγS stalls splicing after B complex formation but prior to spliceosome activation.Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site.U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activityCryo-EM structure of a human spliceosome activated for step 2 of splicing.3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core.GraFix: sample preparation for single-particle electron cryomicroscopy.A protein map of the yeast activated spliceosome as obtained by electron microscopyMapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry.Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.Exon, intron and splice site locations in the spliceosomal B complex.Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex.Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex.Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion.Three-dimensional structure of a pre-catalytic human spliceosomal complex B.Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.
P50
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P50
name
Berthold Kastner
@ast
Berthold Kastner
@en
Berthold Kastner
@nl
type
label
Berthold Kastner
@ast
Berthold Kastner
@en
Berthold Kastner
@nl
prefLabel
Berthold Kastner
@ast
Berthold Kastner
@en
Berthold Kastner
@nl