about
Human platelets can activate peripheral blood B cells and increase production of immunoglobulins.Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.AID-induced remodeling of immunoglobulin genes and B cell fate.Eμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells.Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA contextAnalysis of three genetic markers in IgA nephropathy patients from a single region.Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias.Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.Developmental Switch in the Transcriptional Activity of a Long-Range Regulatory Element.Structurally abnormal immunoglobulins in human immunoproliferative disorders.CSReport: A New Computational Tool Designed for Automatic Analysis of Class Switch Recombination Junctions Sequenced by High-Throughput Sequencing.Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells.Characterization of human FCRL4-positive B cells.A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig productionDeciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory regionImpaired Lysosomal Function Underlies Monoclonal Light Chain-Associated Renal Fanconi SyndromeThe IgH 3' regulatory region controls somatic hypermutation in germinal center B cellsThe IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.The IgH 3' regulatory region and its implication in lymphomagenesis.Toward understanding renal Fanconi syndrome: step by step advances through experimental models.Activation-induced deaminase in B lymphocyte maturation and beyond.Immunoglobulin gene alterations in human heavy chain diseases.First Membrane Proximal External Region-Specific Anti-HIV1 Broadly Neutralizing Monoclonal IgA1 Presenting Short CDRH3 and Low Somatic Mutations.Class-specific effector functions of therapeutic antibodies.AID-driven deletion causes immunoglobulin heavy chain locus suicide recombination in B cells.Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development.Induction of somatic hypermutation by antigen-specific B cell receptors in the human BL2 cell line.Effect of the Emu IgH enhancer on expression of a GFP reporter gene in transfected B cells and transgenic mice.A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy.IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition.Insertion of the IgH locus 3' regulatory palindrome in expression vectors warrants sure and efficient expression in stable B cell transfectants.Membrane isoforms of human immunoglobulins of the A1 and A2 isotypes: structural and functional study.The effect of intron sequences on expression levels of Ig cDNAs.The IgH 3' regulatory region influences lymphomagenesis in Igλ-Myc miceMantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/- mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin.The IgH 3' regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate.B-cell receptor signal strength influences terminal differentiation.
P50
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P50
description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
@en
ricercatore
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研究者
@zh
name
Cogné M
@ast
Cogné M
@es
Cogné M
@nl
Michel Cogné
@en
type
label
Cogné M
@ast
Cogné M
@es
Cogné M
@nl
Michel Cogné
@en
altLabel
Cogné M
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prefLabel
Cogné M
@ast
Cogné M
@es
Cogné M
@nl
Michel Cogné
@en
P108
P1053
D-7370-2015
P106
P31
P496
0000-0002-8519-4427