about
A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescenceC3d of complement as a molecular adjuvant: bridging innate and acquired immunityAberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitisA RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunityLRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertilityATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytesA mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell developmentA DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.Single epitope multiple staining to detect ultralow frequency B cells.Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene ConversionRegulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway.The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA.Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy.Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids.Sequence interpretation. Functional annotation of mouse genome sequences.Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cellsConsequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes.Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways.Pathways for self-tolerance and the treatment of autoimmune diseases.Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndromeRBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertilityA missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouseAutosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100.Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cellsQuantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren's syndrome.Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profilingHENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramersDelayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiencyReliably Detecting Clinically Important Variants Requires Both Combined Variant Calls and Optimized Filtering Strategies.Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
P50
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Christopher C. Goodnow
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Christopher C. Goodnow
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Christopher C. Goodnow
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P31
P496
0000-0001-5296-6155