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pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC)Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' miceKinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonateSoluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMPCrystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonateMolecular details of cAMP generation in mammalian cells: a tale of two systemsCrystal Structure and Regulation Mechanisms of the CyaB Adenylyl Cyclase from the Human Pathogen Pseudomonas aeruginosaIntracellular cAMP signaling by soluble adenylyl cyclase.Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasitesA phosphodiesterase 2A isoform localized to mitochondria regulates respirationSoluble adenylyl cyclase is required for netrin-1 signaling in nerve growth conesSoluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilizationBicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitmentStructure-based development of novel adenylyl cyclase inhibitorsBicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasisCO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicansSoluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium.Modulation of NaCl absorption by [HCO(3)(-)] in the marine teleost intestine is mediated by soluble adenylyl cyclaseCompartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains.Physiological carbon dioxide, bicarbonate, and pH sensingIdentification of a haem domain in human soluble adenylate cyclase.Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclaseA mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling.A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout miceThe soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cellsThe quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicansGastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinaseEndothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.Role of soluble adenylyl cyclase in the heart.Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cellsBicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain.Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils.Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotesFungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence.A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen.Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.
P50
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P50
description
investigador
@es
researcher
@en
name
Jochen Buck
@en
type
label
Jochen Buck
@en
prefLabel
Jochen Buck
@en
P31
P496
0000-0002-3568-5869