P688
Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartinThe TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase RhoThe TSC1 gene product, hamartin, negatively regulates cell proliferationThe tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitinationTSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translationMuscle atrophy in transgenic mice expressing a human TSC1 transgeneThe TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeletonInteraction between hamartin and tuberin, the TSC1 and TSC2 gene productsActivity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioningSomatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia.Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.Aspects of tuberous sclerosis complex (TSC) protein function in the brain
P921
Q22010879-3D218A12-8737-41EF-8C69-C6B50D55B1F8Q22254081-6376F68E-4D17-4C81-AA6B-D3BF32A6A0E1Q22254689-E3BF148C-33E9-4155-A88F-F4EBDFF7F6D1Q24290817-84DBE214-80CA-40F4-B80E-0E6E09BF38D7Q24297576-1D4CAF72-9281-403F-946B-5FC3934F41EAQ24304304-C3DC2233-1D11-466B-9E8A-9982AC7B4ED2Q24306637-AC7589AD-627E-472E-8297-E8FD10459A71Q24314470-957ED3F4-B5F5-4C60-9840-C7CC58FF4544Q24320102-3C287FA5-BAED-4128-9FB3-B42A26AC21D1Q30274618-9B3600A1-D6CA-4B13-AA11-33886CA4C322Q47128935-7D1CD948-9A73-4A80-A2F6-A793ADA9ECEAQ55884164-5e3d41e3-441d-d0b7-5bff-5f99add7f68f
P921
description
Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين في الإنسان العاقل
@ar
name
Hamartin
@de
Hamartina
@pt
Hamartyna
@pl
TSC complex subunit 1
@en
TSC complex subunit 1
@nl
TSC1
@ar
TSC1
@ru
TSC1
@sh
TSC1
@uk
type
label
Hamartin
@de
Hamartina
@pt
Hamartyna
@pl
TSC complex subunit 1
@en
TSC complex subunit 1
@nl
TSC1
@ar
TSC1
@ru
TSC1
@sh
TSC1
@uk
altLabel
TSC1
@de
TSC1
@en
TSC1
@pl
hamartin
@en
truncated hemartin
@en
tuberous sclerosis 1 protein
@en
tumor suppressor
@en
prefLabel
Hamartin
@de
Hamartina
@pt
Hamartyna
@pl
TSC complex subunit 1
@en
TSC complex subunit 1
@nl
TSC1
@ar
TSC1
@ru
TSC1
@sh
TSC1
@uk
P637
P680
P681
P682
P705
P352
P6366
P637
P646
P31
P352
P361
P6366
2776773979
P637
NP_001155898
NP_001155899
NP_001349106
XP_005272268
XP_006717334
XP_011517281
XP_016870585
XP_016870586
XP_016870587
P646
/m/02pkn4s
P680
P681
P682
P702
P703
P705
ENSP00000298552
ENSP00000386093
ENSP00000394524
ENSP00000444017
ENSP00000493608
ENSP00000493639
ENSP00000493773
ENSP00000493963
ENSP00000494104
ENSP00000494365