Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin FamilyStereoselective LSD-like Activity in a Series of d-Lysergic Acid Amides of (R)- and (S)-2-AminoalkanesA Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput ScreeningLysergamides of Isomeric 2,4-Dimethylazetidines Map the Binding Orientation of the Diethylamide Moiety in the Potent Hallucinogenic Agent N , N -Diethyllysergamide (LSD)[1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone as a bioisostere of a carboxylic acid aldose reductase inhibitorDesign, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteinsDesign, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteinsQuinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl seriesStructure of human cytidine deaminase bound to a potent inhibitorMechanism of CDK5/p25 binding by CDK inhibitors3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead findingOrally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosisStructure based drug design: development of potent and selective factor IXa (FIXa) inhibitors3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potencyN2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitorsDual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agentsStructural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase KModulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamidesDiscovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulatorInhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeuticsIdentification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assaysPiperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization.Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptorsNitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophoreTargeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationshipsDiscovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a poPotential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigationFurther structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptorsThe sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesSynthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitorsItraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signalingDiscovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indicationsDiscovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer2-Aminothiazoles as therapeutic leads for prion diseasesSmall molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interactionRational design of potent, small, synthetic allosteric inhibitors of thrombinDesign and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in ratsDiscovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)
P1433
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P1433
description
Wissenschaftliche Fachzeitschrift
@de
peer-reviewed scientific journal
@en
revista científica
@es
revue scientifique
@fr
rivista scientifica
@it
vědecký časopis
@cs
wetenschappelijk tijdschrift van American Chemical Society
@nl
рецензований науковий журнал
@uk
वैज्ञानिक पत्रिका
@hi
英语期刊
@zh
name
Journal of Medicinal Chemistry
@ast
Journal of Medicinal Chemistry
@br
Journal of Medicinal Chemistry
@ca
Journal of Medicinal Chemistry
@co
Journal of Medicinal Chemistry
@da
Journal of Medicinal Chemistry
@de
Journal of Medicinal Chemistry
@en
Journal of Medicinal Chemistry
@es
Journal of Medicinal Chemistry
@fi
Journal of Medicinal Chemistry
@fr
type
label
Journal of Medicinal Chemistry
@ast
Journal of Medicinal Chemistry
@br
Journal of Medicinal Chemistry
@ca
Journal of Medicinal Chemistry
@co
Journal of Medicinal Chemistry
@da
Journal of Medicinal Chemistry
@de
Journal of Medicinal Chemistry
@en
Journal of Medicinal Chemistry
@es
Journal of Medicinal Chemistry
@fi
Journal of Medicinal Chemistry
@fr
altLabel
J. Med. Chem.
@de
J. Med. Chem.
@ja
prefLabel
Journal of Medicinal Chemistry
@ast
Journal of Medicinal Chemistry
@br
Journal of Medicinal Chemistry
@ca
Journal of Medicinal Chemistry
@co
Journal of Medicinal Chemistry
@da
Journal of Medicinal Chemistry
@de
Journal of Medicinal Chemistry
@en
Journal of Medicinal Chemistry
@es
Journal of Medicinal Chemistry
@fi
Journal of Medicinal Chemistry
@fr
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P1058
P1144
P1156
P1159
P1160
J. Med. Chem.
P1277
P1476
Journal of Medicinal Chemistry
@en
P1813
J Med Chem
@en