Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasisThe creatine kinase system and pleiotropic effects of creatineCreatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1.Molecular system bioenergics of the heart: experimental studies of metabolic compartmentation and energy fluxes versus computer modelingMitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calciumThe creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine depositsCreatine kinase and creatine transporter in normal, wounded, and diseased skinMuscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-proteinDifferential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residuesC-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinasePhosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effectsExpression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulationLKB1 is the upstream kinase in the AMP-activated protein kinase cascadeHair bundles are specialized for ATP delivery via creatine kinase.Nucleotide binding to creatine kinase: an isothermal titration microcalorimetry study.Isoenzyme-directed selection and characterization of anti-creatine kinase single chain Fv antibodies from a human phage display library.Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase.New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinases.Tracking and quantification of 32P-labeled phosphopeptides in liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry.Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse.PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysisRegulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cellsHodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis.Structural changes of creatine kinase upon substrate binding.Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation.Functional aspects of creatine kinase in brain.Mitochondrial creatine kinase in human health and disease.Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranesCardiac system bioenergetics: metabolic basis of the Frank-Starling law.New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics.Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin.Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands.Mitochondrial intermembrane inclusion bodies: the common denominator between human mitochondrial myopathies and creatine depletion, due to impairment of cellular energetics.Metabolic compartmentation - a system level property of muscle cells: real problems of diffusion in living cells.Functions and effects of creatine in the central nervous system.The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches.Creatine and creatine kinase in health and disease--a bright future ahead?Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy.The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage.
P50
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P50
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ahli biologi asal Swiss
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bioloog uit Zwitserland
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bitheolaí Eilvéiseach
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biólogo suizo
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زیستشناس سوئیسی
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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Theo Wallimann
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P2038
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