The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesisHERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomesTRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomesHuman Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpointRNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteinsCentrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinaseRNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsUbiquitin-activating enzyme UBA1 is required for cellular response to DNA damageHuman Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activitiesCDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombinationThe cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repairRPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cellsPhosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localizationNonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosisMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancersThe DNA-damage response in human biology and diseaseHuman CtIP promotes DNA end resectionThe combined status of ATM and p53 link tumor development with therapeutic responseUSP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationLoss of Geminin induces rereplication in the presence of functional p53Histone displacement during nucleotide excision repairComplementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitorsDeregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregationRepression of p15INK4b expression by Myc through association with Miz-1MDC1 is required for the intra-S-phase DNA damage checkpointSpatial organization of the mammalian genome surveillance machinery in response to DNA strand breaksAberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing geneDestruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stressRegulation of replication fork progression through histone supply and demandATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damageCell-cycle checkpoints and cancerHuman Asf1 regulates the flow of S phase histones during replicational stressDNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumoursAbnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancerRegulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stabilityDNA replication stress mediates APOBEC3 family mutagenesis in breast cancerMammalian G1- and S-phase checkpoints in response to DNA damage
P50
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P50
description
Czech researcher and university educator
@en
Professor i Cancer Biology
@sv
tschechischer Pädagoge und Akademiker
@de
český vědec a vysokoškolský pedagog
@cs
name
Jiri Bartek
@sq
Jiří Bártek
@ast
Jiří Bártek
@cs
Jiří Bártek
@da
Jiří Bártek
@de
Jiří Bártek
@en
Jiří Bártek
@es
Jiří Bártek
@fo
Jiří Bártek
@fr
Jiří Bártek
@ga
type
label
Jiri Bartek
@sq
Jiří Bártek
@ast
Jiří Bártek
@cs
Jiří Bártek
@da
Jiří Bártek
@de
Jiří Bártek
@en
Jiří Bártek
@es
Jiří Bártek
@fo
Jiří Bártek
@fr
Jiří Bártek
@ga
altLabel
Jiri Bartek
@en
Jiří Bartek
@en
prof. MUDr. Jiří Bartek, DrSc., dr. h. c. mult.
@cs
prefLabel
Jiri Bartek
@sq
Jiří Bártek
@ast
Jiří Bártek
@cs
Jiří Bártek
@da
Jiří Bártek
@de
Jiří Bártek
@en
Jiří Bártek
@es
Jiří Bártek
@fo
Jiří Bártek
@fr
Jiří Bártek
@ga
P166
P214
P1651
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P166
P19
P21
P214
P31
P4872
P569
1953-10-24T00:00:00Z
P691
P734
P735
P7859
viaf-169525808