about
P688
Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicityRedistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's diseaseα-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent mannerAlpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicitySynaptic vesicle trafficking and Parkinson's diseaseParkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitroAlpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recyclingMitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synucleinα-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formationDouble-knockout mice for alpha- and beta-synucleins: effect on synaptic functionsVPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's DiseaseAnkyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's diseaseαβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunctionAlpha-synuclein expression modulates microglial activation phenotypeLoss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged miceSubcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brainAlpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate bindingalpha-Synuclein produces a long-lasting increase in neurotransmitter releaseMice lacking alpha-synuclein are resistant to mitochondrial toxinsSynaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synucleinExpression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineageBrain neutral lipids mass is increased in alpha-synuclein gene-ablated miceAcyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolismRole of alpha-synuclein in synaptic glutamate releaseInhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synucleinAlpha-synuclein cooperates with CSPalpha in preventing neurodegenerationStressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout miceAlpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonismImmune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosusGenetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytesAlpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKIIAltered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathiesIncreased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synucleinMice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine systemSynucleins regulate the kinetics of synaptic vesicle endocytosis.Synucleins Have Multiple Effects on Presynaptic Architecture.
P921
Q24293089-91B39D17-414B-4A52-9C3C-924E368CC9B3Q24299645-B5BD0AD7-8E00-4590-8A99-4106E29662DEQ24300131-9D660CC5-F70C-4EEA-B1F1-3501971A4286Q24301946-280179D8-15E7-4C3F-80AF-F2250594C3B1Q24302024-10DC1235-3FDE-4FEE-836E-5002197637EBQ24311461-590E6288-00B5-4F61-BECE-EA63F21A5743Q24311523-AE123CEA-8489-4506-8B5E-B6CE00801D93Q24537310-9AB67191-FAE8-4DB6-B42C-7AAC603ECD2CQ26269838-9C6D834D-ABB3-4B00-84AC-6BBA2381F4B5Q26269963-EEAAE233-7076-4FAC-A518-BA03A7138768Q28116122-1CD321F9-6990-487C-AEC3-D49EBFD05FFFQ28505185-1ED28FBE-4F6B-47BE-99D1-8B164FA5A80AQ28506296-7B127AB1-780A-4BFD-8E75-AD533ABE6CEDQ28506842-CD37BD3C-35BD-4FF0-B5E4-695C0B345406Q28507051-85987138-EF20-4561-A8C0-FE66A0FDCD65Q28509158-72259765-E6FF-423F-BEAE-4B15CBF837BEQ28510469-9A6F2C0B-0701-482B-8CAD-B1643E94D1EDQ28510893-0AA117F1-7913-45A6-A55E-01BF4D86A53CQ28511475-49A34B53-C9DA-45FC-905C-3DF34AED89D7Q28511573-AC7166B3-1067-41C8-873E-B33114CAB02FQ28512712-B4594777-B579-44E6-AFCB-7F309CD4C275Q28513350-37DD1979-F754-4542-BCC5-B19B6A2FE69AQ28586519-34CD15C2-BFD8-4A90-B4B9-AA748C0142E3Q28586928-56CAD2F0-E637-46B8-A5D1-5C48F35EF413Q28587358-87F9FC8C-5411-4862-BC0D-CF69AF72DEB3Q28587785-3AD0D101-94D4-4EFB-8366-AD30B8F303B3Q28589684-CBEA2DF8-4094-4540-B80D-7C354D5446BBQ28590194-CC0CEA13-74BF-41B3-A046-9204EAF2C08CQ28591255-64F45365-6296-4AAB-818A-1D2AF353D7A7Q28591516-98585E06-7889-4C74-8711-214EEE990F62Q28591581-9FC4AF16-5DA9-4FCE-A5A4-758A86D0AF05Q28591852-ADBE566D-EB52-4174-9DDB-416108F94279Q28593809-7A11B607-66DC-480F-BEA1-24D1EABADC45Q28594502-4982C67B-7BB6-4FD4-A05C-3118609BF9E0Q33865356-8882342B-5DDC-42B8-B253-06078C080D96Q41014171-B1A1F25C-7624-4AD9-984F-2F81BD1E14D8
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Synuclein, alpha
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Synuclein, alpha
@en
Synuclein, alpha
@nl
type
label
Synuclein, alpha
@en
Synuclein, alpha
@nl
altLabel
NACP
@en
Non-A4 component of amyloid precursor
@en
Snca
@en
alpha-synuclein
@en
non-A beta component of AD amyloid
@en
non-A4 component of amyloid
@en
prefLabel
Synuclein, alpha
@en
Synuclein, alpha
@nl
P680
P681
P682
P352
P31
P352
P637
NP_001035916
P680
P681
P682
P702
P703
P705
ENSMUSP00000109907
ENSMUSP00000126067