about
P688
Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infectionEbola virus entry requires the cholesterol transporter Niemann-Pick C1Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathwaysAccumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transportNiemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 bindingAutophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defectsLocalization of the murine Niemann-Pick C1 protein to two distinct intracellular compartmentsA molecular mechanism underlying the neural-specific defect in torsinA mutant miceAmino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice.
P921
Q24292747-1459FE24-255F-45E1-9244-368AD3F5E99EQ24328779-01FCEE03-981B-4011-91DA-40AB0328E428Q24329155-4BFDB45A-8BC9-4183-AC8C-375ED4446521Q24329246-2E50320C-7381-4058-B3DD-58A981250789Q28505513-D0A47B01-944F-4CC7-8423-D0F7E0D8DBEEQ28506553-E832660E-770D-4266-8F9D-671BB8E2E25AQ28585682-37285871-9E0A-47AF-9A1F-DF16436EE087Q28590485-8DCD007D-9380-47F3-A807-3726B4474310Q28593293-3FA9ABD0-C200-4221-87E6-6BDB0A140EA5Q28594816-1A8F6CE7-FFC5-4E09-9B1F-382E44744290Q35217180-ABA8966A-7C2F-430D-809D-6B3BF02F538E
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in NPC intracellular cholesterol transporter 1
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
NPC intracellular cholesterol transporter 1
@en
NPC intracellular cholesterol transporter 1
@nl
type
label
NPC intracellular cholesterol transporter 1
@en
NPC intracellular cholesterol transporter 1
@nl
altLabel
Niemann-Pick type C1
@en
Npc1
@en
niemann-Pick C1 protein
@en
sphingomyelinosis
@en
uniprot:O35604
@en
prefLabel
NPC intracellular cholesterol transporter 1
@en
NPC intracellular cholesterol transporter 1
@nl
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ENSMUSP00000025279