about
Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and ApoptosisGut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme PeroxidasesEffects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signalingIn vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats.Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds.Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.The gut microbiota ellagic acid-derived metabolite urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP).The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells.Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells.Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-γ pathway.Urolithin A causes p21 up-regulation in prostate cancer cells.In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells.Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid.Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-α-dependent gene expression.An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages.Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Model.Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells.Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid.Urolithin A alleviates myocardial ischemia/reperfusion injury via PI3K/Akt pathway.Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells.Urolithin A shows anti-atherosclerotic activity via activation of class B scavenger receptor and activation of Nef2 signaling pathway.Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis.Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A.Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc DegenerationUrolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancerEnhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathwayUrolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
P921
Q21285102-EF72BDDD-2BB5-47DB-BC51-AD71F93B54A0Q28552586-D76D182A-4A0B-494A-8D0C-93517C26A559Q33774655-E20DF0CA-D6F7-4267-987A-B05B8B204A84Q33883650-95A837F0-8A49-4FEF-9E8C-B0FF72D867C3Q34431375-C3F9552F-ABE9-40B8-A880-B12F86A8E604Q34533772-6DBDEBCB-BFFE-4498-B8D9-F0ACC8C678A1Q34668255-45B97646-CC31-4F55-9A1C-B39440C2FC96Q35598535-793E22E1-F031-455E-92BC-2BD329D17F58Q38696781-989686B7-F851-48BC-8552-2E7785B982BCQ38779662-691D8A3A-C2AB-4753-87B3-60C445A17DE8Q38876524-AF624A35-1F61-4FCD-B1B0-64B0894DA6E7Q38882561-A5576FEB-573F-49DB-B8CD-381D940133AEQ41269505-130BDF11-41B1-4534-BBB7-D9C5B7E0EC24Q42838878-E07CE587-62E3-406A-B153-6437968EDBE6Q46285662-1753252E-6049-4887-B55E-1670454C32C2Q47981441-DD9084A5-B3D4-4D81-A537-FBAABC9CEEF4Q48246349-C2FBAED1-573A-426F-BF73-6FC584F37A6FQ50516394-E618BD67-8050-4DAA-8437-93B300A853C8Q51084614-1BC0AD34-E950-4EDD-A2EF-3E5B6B164623Q51731731-27EE84E0-1F2E-4448-8A47-D59B01924D2FQ52585414-E1E54C11-F4AA-4063-9400-9E26604F5243Q54217180-476FF543-937C-459F-8D57-207A83C1B99BQ54940159-2A538B1F-3F4A-4C5D-9EAC-FAC885FE5ACBQ57073792-03FC17B4-CEAA-4A7F-890B-202C78F45CE3Q58599229-008fc0ad-440d-3900-74ff-cd0583ce22d1Q60594391-7a093377-43cf-b9ca-ef4f-081f4782e643Q64094060-04BDF9F4-EB02-4923-87A2-79360B0047DB
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
urolithin A
@en
ウロリチンA
@ja
type
label
urolithin A
@en
ウロリチンA
@ja
altLabel
Uro-A
@en
prefLabel
urolithin A
@en
ウロリチンA
@ja
P527
P592
P661
P662
P129
P2067
228.042259
P231
P233
C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
P234
1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
P235
RIUPLDUFZCXCHM-UHFFFAOYSA-N
P274
P3117
DTXSID40150694
P592
CHEMBL1836264