about
P688
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruptionKinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipidsRole of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's diseasePhosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Microtubule affinity regulating kinase 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
Microtubule affinity regulating kinase 1
@en
type
label
Microtubule affinity regulating kinase 1
@en
altLabel
MAP/microtubule affinity-regulating kinase 1
@en
MARK1
@en
PAR1 homolog c
@en
Par-1c
@en
Par1c
@en
serine/threonine-protein kinase MARK1
@en
prefLabel
Microtubule affinity regulating kinase 1
@en
P361
P527
P637
P680
P681
P682
P705
P352
P637
P31
P352
P361
P527
P637
NP_001273053
NP_001273055
NP_001273057
NP_001273058
XP_005273191
XP_006711389
XP_011507863
XP_011507864
XP_016856794
P680
P682
P702
P703
P705
ENSP00000355884
ENSP00000355885
ENSP00000386017
ENSP00000483424