about
sameAs
LIG1:POLB:SSB(3'poly-dNMP)-dsDNALIG1:POLB:dsDNALIG1:APEX1:PCNA:POLD;POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNALIG1:APEX1:PCNA:POLD;POLE:RPA:RFC:dsDNALIG1;LIG3:XRCC1Joining of adjacent Okazaki fragmentsJoining of adjacent Okazaki fragments of the C-strandLIG1 binds POLB at long-patch BER siteLIG1 and POLB dissociate from repaired dsDNALIG1 binds APEX1 and PCNA at SSBLIG1; APEX1 and PCNA:POLD;POLE:RPA:RFC dissociate from repaired DNADNA ligase I ligates single stranded nick in double stranded DNARemoval of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
P527
P688
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytesThe human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machineryDNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viabilityDistinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair
P921
Q50253200-D5FC6FB6-468C-4F1E-BD1C-4F41CBC2F394Q50253203-2FA850CB-E38B-4279-8600-78A9A572807AQ50253214-A3554D70-3702-4D0C-ABFC-A07ED16F5E85Q50253217-2CEF8E39-B2C9-48E5-BF10-688B4EA9E512Q50253767-F0C76679-85C1-4A45-94BF-AD9F727078A4Q50286084-6E83D7C6-6EC4-4333-B386-969823B529B1Q50286336-A8236106-CE76-4C2F-BDCF-6B6BF15E2F76Q50287238-CD441E9E-344F-401A-9F88-9B6496B253B5Q50287240-E1B09CE3-C226-4865-A38F-324A20D840F9Q50287245-F40103DF-C794-4236-AB81-85531125D7D9Q50287247-3E16E1DA-E356-4B05-A107-1E04C7EF324AQ50287460-65672697-80D1-47AA-91CB-9407451DF803Q50289288-33B11952-002C-4FA2-87B6-597CFA25ADCD
P527
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in DNA ligase 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
DNA ligase 1
@en
type
label
DNA ligase 1
@en
altLabel
DNA ligase I
@en
LIG1
@en
ligase I, DNA, ATP-dependent
@en
polydeoxyribonucleotide synthase [ATP] 1
@en
prefLabel
DNA ligase 1
@en
P361
P527
P637
P680
P681
P682
P705
P352
P638
P31
P352
P361
P527
P637
NP_001275992
NP_001275993
NP_001307899
NP_001307900
XP_024307281
P680
P682
P702
P703
P705
ENSP00000263274
ENSP00000441531
ENSP00000442841
ENSP00000445928
ENSP00000469638
ENSP00000471380
ENSP00000471836
ENSP00000471861
ENSP00000472085
ENSP00000472331