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Alternative end-joining mechanisms: a historical perspective

Alternative end-joining mechanisms: a historical perspective

http://www.wikidata.org/entity/Q21131241

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Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell DNA double-strand break repair pathway choice and cancer Sources of DNA double-strand breaks and models of recombinational DNA repair Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer Genetic instability in budding and fission yeast-sources and mechanisms Microhomology-mediated end joining: new players join the team Mechanism of suppression of chromosomal instability by DNA polymerase POLQ Next-generation mammalian genetics toward organism-level systems biology Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Error-Prone Repair of DNA Double-Strand Breaks.Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner.Applications of CRISPR technologies in research and beyond.Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing Bystander communication and cell cycle decisions after DNA damage Analysis of the role of homology arms in gene-targeting vectors in human cells SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase A role for human homologous recombination factors in suppressing microhomology-mediated end joining Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain Mechanistic Modelling and Bayesian Inference Elucidates the Variable Dynamics of Double-Strand Break Repair.Accurate Breakpoint Mapping in Apparently Balanced Translocation Families with Discordant Phenotypes Using Whole Genome Mate-Pair Sequencing.NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres.Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.Local sequence assembly reveals a high-resolution profile of somatic structural variations in 97 cancer genomes.Risky business: Microhomology-mediated end joining.Signaling of double strand breaks and deprotected telomeres in Arabidopsis The DNA resection protein CtIP promotes mammary tumorigenesis.Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination.Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.DNA double-strand breaks and telomeres play important roles in trypanosoma brucei antigenic variation.Characterization of a novel large deletion caused by double-stranded breaks in 6-bp microhomologous sequences of intron 11 and 12 of the F13A1 gene.Protecting DNA from errors and damage: an overview of DNA repair mechanisms in plants compared to mammals.Regulation of non-homologous end joining via post-translational modifications of components of the ligation step.CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani.Targeted recombination between homologous chromosomes for precise breeding in tomato.Agrobacterium T-DNA integration into the plant genome can occur without the activity of key non-homologous end-joining proteins.Genome engineering with TALENs and ZFNs: repair pathways and donor design.Optimized CRISPR-Cas9 Genome Editing for Leishmania and Its Use To Target a Multigene Family, Induce Chromosomal Translocation, and Study DNA Break Repair Mechanisms.Expression and localization of GEN1 in mouse mammary epithelial cells.

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Alternative end-joining mechanisms: a historical perspective

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2013 nî lūn-bûn

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Anabelle Decottignies

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P2860

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)

Biochemical evidence for Ku-independent backup pathways of NHEJ

53BP1 regulates DSB repair using Rif1 to control 5' end resection

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.

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