Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease
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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal traffickingRNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense interventionC9orf72 expansions are the most common genetic cause of Huntington disease phenocopiesUnconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALSThere has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALSImpaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron DegenerationGolgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport VesiclesConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisDiscovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-IIMolecular architecture and function of the SEA complex, a modulator of the TORC1 pathway.C9orf72's Interaction with Rab GTPases-Modulation of Membrane Traffic and AutophagyA perspective on stem cell modeling of amyotrophic lateral sclerosisRNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosisMultiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulatorLoss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell deathA C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagyThe ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB SignalingC9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo.Bioinformatics Data Mining Approach Suggests Coexpression of AGTPBP1 with an ALS-linked Gene C9orf72.Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development.Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansionC9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysisC9orf72 amyotrophic lateral sclerosis and frontotemporal dementia: gain or loss of function?TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic diseaseHypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier.Folliculin contributes to VHL tumor suppressing activity in renal cancer through regulation of autophagy.Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegansFolliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.Bromodomain inhibitors regulate the C9ORF72 locus in ALSSEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences.Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein.C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAsReview series: Rab GTPases and membrane identity: causal or inconsequential?Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathwaysRecruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
P2860
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P2860
Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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label
Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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Discovery of Novel DENN Protei ...... e Structures and Human Disease
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P2860
P50
P3181
P356
P1476
Discovery of Novel DENN Protei ...... e Structures and Human Disease
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P2860
P3181
P356
10.3389/FGENE.2012.00283
P407
P577
2012-01-01T00:00:00Z