about
P688
Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulatorLoss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell deathA C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagyThe ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.
P921
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
SMCR8-C9orf72 complex subunit
@en
SMCR8-C9orf72 complex subunit
@nl
type
label
SMCR8-C9orf72 complex subunit
@en
SMCR8-C9orf72 complex subunit
@nl
altLabel
SMCR8
@en
Smith-Magenis syndrome chromosome region, candidate 8
@en
guanine nucleotide exchange protein SMCR8
@en
smith-Magenis syndrome chromosomal region candidate gene 8 protein
@en
prefLabel
SMCR8-C9orf72 complex subunit
@en
SMCR8-C9orf72 complex subunit
@nl
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ENSP00000385025
ENSP00000492062