Extreme evolutionary disparities seen in positive selection across seven complex diseases
about
Gene flow from North Africa contributes to differential human genetic diversity in southern EuropeSnpdat: Easy and rapid annotation of results from de novo snp discovery projects for model and non-model organismsFine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility lociG-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritisA search for genetic diversity among Italian Greyhounds from Continental Europe and the USA and the effect of inbreeding on susceptibility to autoimmune diseaseAutoimmune effector memory T cells: the bad and the goodG protein signaling modulator-3: a leukocyte regulator of inflammation in health and diseasePhylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations.Wrapper-based selection of genetic features in genome-wide association studies through fast matrix operations.Transcriptome sequencing and analysis of wild Amur Ide (Leuciscus waleckii) inhabiting an extreme alkaline-saline lake reveals insights into stress adaptationDirectional selection causes decanalization in a group I ribozyme.An evolutionary perspective on epistasis and the missing heritabilityAnalysis of the genetic basis of disease in the context of worldwide human relationships and migration.Genetics of type 2 diabetes-pitfalls and possibilities.Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11.Human genomic disease variants: a neutral evolutionary explanation.A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease.Progress in multiple sclerosis genetics.Cross-comparison of the genome sequences from human, chimpanzee, Neanderthal and a Denisovan hominin identifies novel potentially compensated mutations.Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome.Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundanceCommon risk alleles for inflammatory diseases are targets of recent positive selectionChanges in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selectionReduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model.Disease consequences of human adaptation.Implications of sex-specific selection for the genetic basis of disease.No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.The immunogenetic architecture of autoimmune disease.A genomic perspective on HLA evolution.Population structure from NOS genes correlates with geographical differences in coronary incidence across Europe.Natural selection and type 2 diabetes-associated mortality in an isolated indigenous community in the valley of Oaxaca, southern Mexico.Evolutionary Nephrology.Triangulation of the human, chimpanzee, and Neanderthal genome sequences identifies potentially compensated mutations.Signatures of Long-Term Balancing Selection in Human Genomes.
P2860
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P2860
Extreme evolutionary disparities seen in positive selection across seven complex diseases
description
2010 nî lūn-bûn
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2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@ast
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@en
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@en-gb
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@nl
type
label
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@ast
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@en
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@en-gb
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@nl
altLabel
Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases
@en
prefLabel
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@ast
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@en
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@en-gb
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@nl
P2860
P3181
P1433
P1476
Extreme evolutionary disparities seen in positive selection across seven complex diseases
@en
P2093
Erik Corona
Joel T Dudley
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0012236
P407
P50
P577
2010-01-01T00:00:00Z