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GLI:SUFUGLI:SUFU [ciliary tip]GLI:SUFU [ciliary base]GLI3:SUFUp6S-GLI3:SUFUp10S-GLI3:SUFUp13S-GLI3:SUFU4xub-p13S-Gli3:SUFUGLI2:SUFUp4S-GLI2:SUFUp8S-GLI2:SUFUp11S-GLI2:SUFUub-p11S-GLI2:SUFUGLI1-SUFU complexpS-GLI1:SUFUub-pS-GLI1:SUFUNUMB:ITCH:ub-pS-GLI1:SUFUULK3:SUFUGLI proteins bind SUFUGLI3 is partially degraded by the proteasome to yield the GLI3 repressorGLI2 is degraded by the proteasomeGLI1 is degraded by the proteasome after ubiquitination by beta-TrCPGLI1 is degraded by the proteasome after ubiquitination by ITCHGLI:SUFU dissociatesULK3:SUFU dissociates
P527
P688
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor GliGli regulation by the opposing activities of fused and suppressor of fusedThe sonic hedgehog-patched-gli pathway in human development and diseaseDual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathwaySCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.
P921
Q50273852-6382ED31-EDCB-4244-9ACE-74C978D3A7A9Q50273854-DC0F734B-E92A-4D2A-AB8F-EA3080A9DE3DQ50273859-2E4B99CF-DE42-46BF-8678-0D2893F016E5Q50273874-388E7A58-81F8-4639-B0A0-2E75E91F4E61Q50273875-0B3578B0-9DB2-4592-9A6C-CC4F226D540EQ50273876-E40C5730-6D15-4605-8FDE-405343C5A989Q50273877-3B2E44B0-CFB5-48C2-9BCE-37826F83172FQ50273878-1134E5B0-6960-41B4-92FA-C1071EC8B94CQ50273883-C0E4E1A8-FAC1-403C-9869-8B2C5BC5CE90Q50273884-705803EC-B07D-46AA-B6F4-58CD5C6B6C46Q50273885-C617D354-9FAC-4CB1-925E-33050803C583Q50273886-9A040BBA-0025-4845-82C3-342D8462492EQ50273887-9A9FDC1B-A057-45CA-A0DD-651ECD3592B7Q50273888-6B577351-A13A-4344-8A7D-3F04E7E18275Q50273889-36E3D22C-7D37-4193-9559-DA281B2D1B31Q50273890-039A0337-5093-414E-94D8-2BD9D717BE76Q50273892-08B93B6B-AB32-4110-9212-A31947E94A36Q50273917-64F26CD8-84D1-482B-B74A-0E677065371BQ50298918-EB29E895-2E29-4E38-BBC2-E5BD05E173CDQ50298931-69EB35A8-A6C5-47C3-94EA-DF2C826E50D2Q50298944-2DC248B5-A2D4-49C6-928F-CA229ABC0C93Q50298947-B8B434D5-AE8F-48A0-8DDA-CAFB21908AF6Q50298950-7D1C5476-A1A0-4964-9D68-9B040091013BQ50298970-91500989-6D10-4709-84DF-E29910416272Q50298972-CF8BF74D-0D6E-47FB-B3BA-E1D2864F60AC
P527
Q22010791-177760EF-8468-414F-96B2-4810C7624667Q22010803-B1535AEF-579D-445C-8B71-91B799481DABQ22254079-F5FF36FC-4C3B-4B25-ABEB-772D1205CF4EQ24290288-1E3DF300-DA54-4C16-8B09-C17515D4B439Q24339384-91C5BF47-3979-4146-9220-A720585C8E78Q38768033-E96FF982-BB74-4A3D-850E-42FD5A0C7DFAQ46233034-AC457FB9-8939-4592-B276-10C80033AA2C
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteinë
@sq
proteïne in SUFU negative regulator of hedgehog signaling
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
SUFU negative regulator of hedgehog signaling
@en
type
label
SUFU negative regulator of hedgehog signaling
@en
altLabel
SUFU
@en
negative regulator of hedgehog signaling
@en
suppressor of fused homolog
@en
prefLabel
SUFU negative regulator of hedgehog signaling
@en
P361
P637
P638
P680
P681
P682
P705
P352
P279
P31
P352
P361
P637
NP_001171604
XP_011538160
XP_011538162
XP_011538163
XP_011538165
XP_011538166
XP_016871812
P638
P680
P682
P702
P703
P705
ENSP00000358915
ENSP00000358918
ENSP00000411597