Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells.
about
Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline)8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applicationsImage-based screening for the identification of novel proteasome inhibitors.Cancer stem/progenitor cell active compound 8-quinolinol in combination with paclitaxel achieves an improved cure of breast cancer in the mouse modelNitrogen substituent polarity influences dithiocarbamate-mediated lipid oxidation, nerve copper accumulation, and myelin injury.Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cellsTumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells.A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases.Comparative activities of nickel(II) and zinc(II) complexes of asymmetric [NN'O] ligands as 26S proteasome inhibitors.Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives.Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer: a challenge for the future.Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis.The ubiquitin-proteasome system and assays to determine responses to inhibitors.Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base-copper complexes.High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.Recent advances in proteasome inhibitor discovery.Gold(III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: preclinical studies against human breast neoplasia.Proteasome inhibitor patents (2010 - present).High resolution short focal distance Bent Crystal Laue Analyzer for copper K edge x-ray absorption spectroscopy.Modulation of the tumor cell death pathway by androgen receptor in response to cytotoxic stimuli.In vitro and in vivo antitumor activities and DNA binding mode of five coordinated cyclometalated organoplatinum(II) complexes containing biphosphine ligands.Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells.Pharmacological activity of metal binding agents that alter copper bioavailability.The biology of incipient, pre-invasive or intraepithelial neoplasia.Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells.1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity.A novel dithiocarbamate analogue with potentially decreased ALDH inhibition has copper-dependent proteasome-inhibitory and apoptosis-inducing activity in human breast cancer cellsRelationship between the methylation status of dietary flavonoids and their growth-inhibitory and apoptosis-inducing activities in human cancer cellsMobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer MechanismNovel metals and metal complexes as platforms for cancer therapyPyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity.Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes.The tumor proteasome as a novel target for gold(III) complexes: implications for breast cancer therapyInduction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activityNovel 8-hydroxylquinoline analogs induce copper-dependent proteasome inhibition and cell death in human breast cancer cells.Turning tumor-promoting copper into an anti-cancer weapon via high-throughput chemistryMolecular study on copper-mediated tumor proteasome inhibition and cell death.Pharmacotherapeutic targets in Alzheimer's diseaseEffects of tethered ligands and of metal oxidation state on the interactions of cobalt complexes with the 26S proteasome.
P2860
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P2860
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
name
Clioquinol and pyrrolidine dit ...... s in human breast cancer cells
@nl
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@ast
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@en
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@en-gb
type
label
Clioquinol and pyrrolidine dit ...... s in human breast cancer cells
@nl
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@ast
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@en
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@en-gb
prefLabel
Clioquinol and pyrrolidine dit ...... s in human breast cancer cells
@nl
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@ast
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@en
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@en-gb
P2093
P2860
P3181
P356
P1476
Clioquinol and pyrrolidine dit ...... in human breast cancer cells.
@en
P2093
Fred R Miller
Kenyon G Daniel
Q Ping Dou
Qiuzhi Cindy Cui
Shirley Orlu
P2860
P2888
P304
P3181
P356
10.1186/BCR1322
P407
P577
2005-09-20T00:00:00Z
P5875
P6179
1017093322