Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells.
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Chinese Herbs Interfering with Cancer Reprogramming MetabolismAdipose tissue dysfunction and its effects on tumor metabolismAnti-tumor effects of shikonin derivatives on human medullary thyroid carcinoma cells.β,β-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species.Both Phenolic and Non-phenolic Green Tea Fractions Inhibit Migration of Cancer CellsCbl-b-regulated extracellular signal-regulated kinase signaling is involved in the shikonin-induced apoptosis of lung cancer cells in vitro.Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.Integration of Different "-omics" Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia CellsMitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds.Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer.Antagonistic effects of acetylshikonin on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1.Targeting cancer cell mitochondria as a therapeutic approach: recent updates.Shikonin induces necroptosis by reactive oxygen species activation in nasopharyngeal carcinoma cell line CNE-2Z.RIP1K and RIP3K provoked by shikonin induce cell cycle arrest in the triple negative breast cancer cell line, MDA-MB-468: necroptosis as a desperate programmed suicide pathway.Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway.Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib.Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity.Shikonin promotes autophagy in BXPC-3 human pancreatic cancer cells through the PI3K/Akt signaling pathway.Involvement of LeMRP, an ATP-binding cassette transporter, in shikonin transport and biosynthesis in Lithospermum erythrorhizon.Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance.RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment.Shikonin causes apoptosis by disrupting intracellular calcium homeostasis and mitochondrial function in human hepatoma cells.Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis.Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology.
P2860
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P2860
Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells.
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Shikonin directly targets mito ...... al dysfunction in cancer cells
@nl
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@ast
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@en
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@en-gb
type
label
Shikonin directly targets mito ...... al dysfunction in cancer cells
@nl
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@ast
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@en
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@en-gb
altLabel
Shikonin Directly Targets Mito ...... al Dysfunction in Cancer Cells
@en
prefLabel
Shikonin directly targets mito ...... al dysfunction in cancer cells
@nl
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@ast
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@en
Shikonin directly targets mito ...... l dysfunction in cancer cells.
@en-gb
P2093
P2860
P3181
P356
P1476
Shikonin directly targets mito ...... al dysfunction in cancer cells
@en
P2093
Benjamin Wiench
Malte Paulsen
Tolga Eichhorn
P2860
P304
P3181
P356
10.1155/2012/726025
P407
P577
2012-10-15T00:00:00Z