SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
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Evidence that SOX2 overexpression is oncogenic in the lungThe PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinomaSox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancerYin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implicationParadoxical role of SOX2 in gastric cancerThe role of SOX2 in small cell lung cancer, lung adenocarcinoma and squamous cell carcinoma of the lungLong non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesisPulmonary adenocarcinoma: a renewed entity in 2011Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors.High expression of SOX2 is associated with poor prognosis in patients with salivary gland adenoid cystic carcinomaSOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines.Epithelial cell transforming sequence 2 in human oral cancer.ALK-rearrangements and testing methods in non-small cell lung cancer: a reviewGenomics of squamous cell lung cancerLung cancer stem cell: new insights on experimental models and preclinical data.Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinomaTransforming growth factor-beta signaling network regulates plasticity and lineage commitment of lung cancer cells.Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity.Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomasSOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells.Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinomaTrue 3q chromosomal amplification in squamous cell lung carcinoma by FISH and aCGH molecular analysis: impact on targeted drugsMolecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes.High SOX2 levels predict better outcome in non-small cell lung carcinomas.Sox2 gene amplification significantly impacts overall survival in serous epithelial ovarian cancerPrognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma.The prognostic value of SOX2 expression in non-small cell lung cancer: a meta-analysisFAM83B is a novel biomarker for diagnosis and prognosis of lung squamous cell carcinoma.Classification of non-small cell lung cancer based on copy number alterationsSox2 activates cell proliferation and differentiation in the respiratory epithelium.Identification of novel genomic aberrations in AML-M5 in a level of array CGHIncreased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease.Increased Levels of Circulating and Tissue mRNAs of Oct-4, Sox-2, Bmi-1 and Nanog is ESCC Patients: Potential Tool for Minimally Invasive Cancer Diagnosis.Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer.The role of SOX-2 on the survival of patients with non-small cell lung cancerThe evolving role of the pathologist in the management of lung cancer.Sex-determining region Y-box 2 expression predicts poor prognosis in human ovarian carcinoma.
P2860
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P2860
SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
description
2010 nî lūn-bûn
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2010 թուականին հրատարակուած գիտական յօդուած
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2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
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2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@ast
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@en
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@en-gb
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@nl
type
label
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@ast
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@en
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@en-gb
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@nl
altLabel
SOX2 Is an Oncogene Activated ...... Lung Squamous Cell Carcinomas
@en
prefLabel
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@ast
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@en
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@en-gb
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@nl
P2093
P2860
P50
P3181
P1433
P1476
SOX2 is an oncogene activated ...... lung squamous cell carcinomas
@en
P2093
Bernard Jost
Doulaye Dembelé
Joerg Huelsken
Julien Exinger
Nadine Martinet
Soraya Dali
Thomas Hussenet
P2860
P3181
P356
10.1371/JOURNAL.PONE.0008960
P407
P577
2010-01-01T00:00:00Z