Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability - Wikidata - wikimedia - TriplyDB

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability

http://www.wikidata.org/entity/Q21563509

about

Emergence of switch-like behavior in a large family of simple biochemical networks Construction and analysis of a modular model of caspase activation in apoptosis Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switch Small RNAs establish delays and temporal thresholds in gene expression Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9 ON/OFF and beyond--a boolean model of apoptosis Operating regimes of signaling cycles: statics, dynamics, and noise filtering Computational insights on the competing effects of nitric oxide in regulating apoptosis Mathematical modelling of cell-fate decision in response to death receptor engagement Modeling a snap-action, variable-delay switch controlling extrinsic cell death Bistability in apoptosis by receptor clustering STL-based analysis of TRAIL-induced apoptosis challenges the notion of type I/type II cell line classification Systems modeling of anti-apoptotic pathways in prostate cancer: psychological stress triggers a synergism pattern switch in drug combination therapy Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states Loads bias genetic and signaling switches in synthetic and natural systems Power-Law Modeling of Cancer Cell Fates Driven by Signaling Data to Reveal Drug Effects ViscumTT induces apoptosis and alters IAP expression in osteosarcoma in vitro and has synergistic action when combined with different chemotherapeutic drugs Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death Warning signals for eruptive events in spreading fires.Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data Bimodal and hysteretic expression in mammalian cells from a synthetic gene circuit.Multistable decision switches for flexible control of epigenetic differentiation.Sophisticated framework between cell cycle arrest and apoptosis induction based on p53 dynamics.Coherent activation of a synthetic mammalian gene network.From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine.Modeling the TNFα-induced apoptosis pathway in hepatocytes.A trigger model of apoptosis induced by tumor necrosis factor signaling.Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells Global analysis of dynamical decision-making models through local computation around the hidden saddle.A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation Protein scaffolds can enhance the bistability of multisite phosphorylation systems.Programming biological models in Python using PySB Modeling dynamics of cell-to-cell variability in TRAIL-induced apoptosis explains fractional killing and predicts reversible resistance Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior.Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.Computational modeling of apoptotic signaling pathways induced by cisplatin Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization.RMOD: a tool for regulatory motif detection in signaling network.Modeling heterogeneous responsiveness of intrinsic apoptosis pathway

P2860

Q21145326-78F7E4F6-2811-4C2D-809B-0FEA7624FA40 Q21245220-E2E9401E-E006-4B6C-9C52-F3B3D4FC7134 Q21562302-B76D44CE-3EFA-4E53-8208-8E428453DBCF Q24646228-8B39E52F-A1E2-47CD-8B87-9E23E755569A Q24669658-A2D9AB0B-4320-4D8B-A711-E473A473D9F6 Q28472140-E9406BA5-DAD0-4A6A-8214-650DA7CF1587 Q28472165-48B408F4-31BC-42AF-AB94-29A29552DC9F Q28472789-8756B31D-9BF5-4A0D-9050-AA49632D4966 Q28473094-9BE27550-241A-42D5-8461-A9B15B5C5CE2 Q28474253-F22457D5-CB7F-4078-ABA2-5A54064D77E7 Q28475785-0142EF96-25DA-4A7A-A367-FDB777C4A4FC Q28487858-0A944485-D5FF-4591-BF01-AB93F2F09A3F Q28536000-754CEA5E-9E38-4D25-82D5-039DADB3A2BC Q28537725-E62E0192-0F87-4A80-AB67-E3F0292556FD Q28541592-E0C96FA8-EEC3-4355-926D-D669632FBAB4 Q28552821-32EEDD72-A9D5-437D-84D8-366080D1E614 Q28583456-456A8BF6-7279-4FF6-AFA3-9393C9C23EF9 Q30493467-93BA9A1F-6AF1-47FA-9A03-6A54CACB4551 Q30623703-5D728003-8BB8-4ADF-900E-7DCDE5B7E2F6 Q31138672-44F6DB35-6AFD-4F82-80B6-82F743BDCA6C Q33340290-5C07BAFC-49F1-4B30-BC9A-92416793F22A Q33388197-D837AE2F-E00F-4DD5-89F8-76E3F83C1810 Q33416400-D5C283D8-E083-49AA-AFDE-E873ECCFB100 Q33629305-2D0F0113-2D6C-45EA-8968-9005B3902A9E Q33720383-E8E4C175-CF5D-4DEF-A868-16C68BAED5CD Q33886203-B4C6238A-1412-4569-86E2-3BCFF1326237 Q33937482-D75BDED8-F961-444F-A79F-AEC36744F696 Q34069986-8B9DCF3A-30E6-452E-83BB-402D61185FFB Q34192940-9BD88A7E-D5DE-49B9-AC6A-8A9DD10C085B Q34206126-96AB5C97-543A-4A5F-BE5E-1350980C42BF Q34249137-DD43A3B5-2EE6-4605-A9A6-E726F9A0E7E8 Q34318172-FBB988B9-775E-4496-BEFF-F4FEC313210E Q34328597-FE518CB8-6C35-45C0-B3A6-709C973AC9FC Q34393708-D0FE6265-C25C-4BD7-A18A-CA69F946B6A5 Q34395461-A9C70AAB-C4D1-48E9-AA8C-0FA559E61400 Q34400187-F95EF7F1-CAC9-4290-8B2E-B3A18EB03943 Q34411477-409F33A7-545C-4411-AD43-6A71A3475A33 Q34671696-CDE8D5EE-40A9-41A6-AC10-678BA6164FAC Q34848389-4CEC6029-E48F-4B20-B29A-5B9C23AF23CA Q34856232-85BB42DA-BAA3-4536-9D8E-C6D453EC7F14

P2860

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability

http://www.wikidata.org/entity/Q21563509

description

2006 nî lūn-bûn

@nan

2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Mathematical modeling identifi ...... itive feedback and bistability

@ast

Mathematical modeling identifi ...... itive feedback and bistability

@en

Mathematical modeling identifi ...... itive feedback and bistability

@en-gb

Mathematical modeling identifi ...... itive feedback and bistability

@nl

type

label

Mathematical modeling identifi ...... itive feedback and bistability

@ast

Mathematical modeling identifi ...... itive feedback and bistability

@en

Mathematical modeling identifi ...... itive feedback and bistability

@en-gb

Mathematical modeling identifi ...... itive feedback and bistability

@nl

altLabel

Mathematical Modeling Identifi ...... itive Feedback and Bistability

@en

prefLabel

Mathematical modeling identifi ...... itive feedback and bistability

@ast

Mathematical modeling identifi ...... itive feedback and bistability

@en

Mathematical modeling identifi ...... itive feedback and bistability

@en-gb

Mathematical modeling identifi ...... itive feedback and bistability

@nl

P1433

Q21563509-6F57938D-61EA-4D4A-A0F8-7AD03BC4744C

P1476

Q21563509-04C7E226-ABE6-4EB9-9594-4EF6D3C0B9E7

P2860

Q21563509-01547F48-7FF0-42E7-AE8E-F28F61B8050D

Q21563509-046970F0-FB94-4EC5-B7DB-A5B31C3E641F

Q21563509-06DF288F-BC9D-4419-A68B-FD0DBB2FD9FB

Q21563509-098004F4-AF6C-4194-9864-3DA178A30A45

Q21563509-0F7206C2-C5EE-499B-86AB-A3CE4B45DF93

Q21563509-0FDFA5B7-04D7-44A9-9847-0961E3B40E44

Q21563509-122E12F6-B4E2-43C3-A856-A68FC95DF53A

Q21563509-12F58398-0C92-485C-81C6-6950AB49CF4D

Q21563509-13555D72-B5B0-40FF-A5FD-8897D2ACB326

Q21563509-154F76BB-6CD6-48DF-9D8D-77CE8DD729BA

P304

Q21563509-13CC049A-ADE3-4DF5-9323-6B906D71C62B

P31

Q21563509-62927990-AEA8-4378-A6BD-DF5D5AB641CA

P3181

Q21563509-BFDA5FDB-1E66-4903-8CBA-309E3751821C

P356

Q21563509-9B212FC4-3EDD-4DFC-9753-0D65BEF334DF

P407

Q21563509-CE926D43-11D7-4062-A380-5EAFE0DFD1B5

P433

Q21563509-29119816-982C-43FA-867C-E0DEC0C19537

P478

Q21563509-3E7413D7-B912-422A-BFAF-9BE45DD2365C

P50

Q21563509-04C9FB47-39AF-496F-98FA-F22B8A98386C

Q21563509-C9FA6586-B9A5-45B3-B7CA-97367EC3FA73

Q21563509-CEABD472-3157-450B-819A-060D16AC9F1D

P577

Q21563509-C464CD39-E8B3-405E-BF75-84A6A1F7704E

P5875

Q21563509-1B8AA97B-6C17-4D18-AFCE-B33CB029CDA2

P698

Q21563509-D2E1B58C-DF0E-4DA7-A7F3-DA605D8E1216

P921

Q21563509-5DEFA863-78A9-46D4-AAEB-29741AC66181

P932

Q21563509-01951850-35BE-4E34-A79F-301560F43016

P3181

P356

JOURNAL.PCBI.0020120

P1433

PLOS Computational Biology

P1476

Mathematical modeling identifi ...... itive feedback and bistability

@en

P2860

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

Structural basis for the inhibition of caspase-3 by XIAP

Mechanism of XIAP-mediated inhibition of caspase-9

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

X-linked IAP is a direct inhibitor of cell-death proteases

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c

P304

e120

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2839206

http://www.w3.org/2001/XMLSchema#string

P356

10.1371/JOURNAL.PCBI.0020120

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

2

http://www.w3.org/2001/XMLSchema#string

P50

Hanspeter Herzel

P577

2006-09-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6816243

http://www.w3.org/2001/XMLSchema#string

P698

16978046

http://www.w3.org/2001/XMLSchema#string

P921

apoptotic process

P932

1570177

http://www.w3.org/2001/XMLSchema#string