about
P688
A new protein containing an SH2 domain that inhibits JAK kinasesDeletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivoJANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathwayStructure and function of a new STAT-induced STAT inhibitorTRIM8/GERP RING finger protein interacts with SOCS-1Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsThe SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivoMutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activationPim serine/threonine kinases regulate the stability of Socs-1 proteinThe transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.
P921
Q24313242-E5426958-41FA-40DD-855F-4A7F4883AA0DQ24530013-BAA2AFD9-6477-4CDB-8BD0-04D08B8EDB62Q28511490-92296065-6F00-4E19-9C3A-C3F3755AB7A1Q28567187-0FFD53A7-CC20-4C84-9776-828B44A95B8EQ28584775-4053635B-B916-46BE-A828-C767932C2EF1Q28585180-BF13D5E6-BD61-4742-AE8D-1A8B4C4998C2Q28586863-FC3CD359-6827-47EE-807A-B641F18C96DBQ28588059-0A9E5F2B-71EF-40B1-8BB8-AD7E4577DE5AQ28588105-385E0CBC-47C8-466E-AA30-529BD5F834F4Q28590220-5D6F67B7-9D04-46BB-B65D-71A8472CD5FDQ28594323-7DDFC521-4D63-47B9-BA42-302CDEC7CAFAQ45345537-4E3C3F68-C4BB-46F2-8013-C3410578D407
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Suppressor of cytokine signaling 1
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Suppressor of cytokine signaling 1
@en
Suppressor of cytokine signaling 1
@nl
type
label
Suppressor of cytokine signaling 1
@en
Suppressor of cytokine signaling 1
@nl
altLabel
JAB
@en
JAK-binding protein
@en
JAK2-binding protein
@en
SSI-1
@en
STAT-induced STAT inhibitor 1
@en
Socs1
@en
cytokine inducible SH2-containing protein 1
@en
cytokine inducible SH2-containing protein 7
@en
suppressor of cytokine signaling 1
@en
prefLabel
Suppressor of cytokine signaling 1
@en
Suppressor of cytokine signaling 1
@nl
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NP_001258532
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ENSMUSP00000038121
ENSMUSP00000155530