NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway
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BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cellsIdentification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interactionInteraction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domainsThe docking protein HEF1 is an apoptotic mediator at focal adhesion sitesAND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphologySplice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signalingNSP-Cas protein structures reveal a promiscuous interaction module in cell signalingRIP2 is a Raf1-activated mitogen-activated protein kinase kinaseProteolysis of the docking protein HEF1 and implications for focal adhesion dynamicsThe serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundleProtein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell linesNSP-CAS Protein Complexes: Emerging Signaling Modules in CancerAssociation of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistanceA novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1ALoss of AND-34/BCAR3 expression in mice results in rupture of the adult lensBreast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas)The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein CasBreast cancer antiestrogen resistance 3-p130Cas interactions promote adhesion disassembly and invasion in breast cancer cells.Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane rufflingBCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signalingChat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways.A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells.Synthetic lethal screen of an EGFR-centered network to improve targeted therapies.AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern.Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.Characterization of the Rx1-dependent transcriptome during early retinal development.Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex.Bcar3 is expressed in sertoli cells and germ cells of the developing testis in mice.
P2860
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P2860
NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
NSP1 defines a novel family of ...... otein kinase signaling pathway
@ast
NSP1 defines a novel family of ...... otein kinase signaling pathway
@en
NSP1 defines a novel family of ...... otein kinase signaling pathway
@en-gb
NSP1 defines a novel family of ...... otein kinase signaling pathway
@nl
type
label
NSP1 defines a novel family of ...... otein kinase signaling pathway
@ast
NSP1 defines a novel family of ...... otein kinase signaling pathway
@en
NSP1 defines a novel family of ...... otein kinase signaling pathway
@en-gb
NSP1 defines a novel family of ...... otein kinase signaling pathway
@nl
prefLabel
NSP1 defines a novel family of ...... otein kinase signaling pathway
@ast
NSP1 defines a novel family of ...... otein kinase signaling pathway
@en
NSP1 defines a novel family of ...... otein kinase signaling pathway
@en-gb
NSP1 defines a novel family of ...... otein kinase signaling pathway
@nl
P2093
P2860
P921
P3181
P356
P1476
NSP1 defines a novel family of ...... otein kinase signaling pathway
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.274.15.10047
P407
P577
1999-04-09T00:00:00Z