The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor
about
Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1Transition-state inhibitors of purine salvage and other prospective enzyme targets in malariaThe structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferaseCrystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferaseClosed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migrationCrystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor designCrystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferaseStructural complexes of human adenine phosphoribosyltransferase reveal novel features of the APRT catalytic mechanismA phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPTStructures of hypoxanthine-guanine phosphoribosyltransferase (TTHA0220) fromThermus thermophilusHB8Structure of Salmonella typhimurium OMP Synthase in a Complete Substrate ComplexAcyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine PhosphoribosyltransferaseThe adenine phosphoribosyltransferase from Giardia lamblia has a unique reaction mechanism and unusual substrate binding propertiesAn inquiry into protein structure and genetic disease: introducing undergraduates to bioinformatics in a large introductory courseVirtual screening of combinatorial libraries across a gene family: in search of inhibitors of Giardia lamblia guanine phosphoribosyltransferase.Pyrophosphate activation in hypoxanthine--guanine phosphoribosyltransferase with transition state analoguePurine phosphoribosyltransferases.Severe gouty arthritis and mild neurologic symptoms due to F199C, a newly identified variant of the hypoxanthine guanine phosphoribosyltransferase.Loop residues and catalysis in OMP synthase.Prediction of protein deamidation rates from primary and three-dimensional structure.Signal Peptidase Complex Subunit 1 and Hydroxyacyl-CoA Dehydrogenase Beta Subunit Are Suitable Reference Genes in Human LungsGenotype-phenotype correlations in Lesch-Nyhan disease: moving beyond the gene.Purine and pyrimidine pathways as targets in Plasmodium falciparum.Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum.ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1.Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.Plasmodium falciparum: new molecular targets with potential for antimalarial drug development.Genotype-phenotype correlations in neurogenetics: Lesch-Nyhan disease as a model disorder.From crystal to compound: structure-based antimalarial drug discovery.Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidinesAcyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.Synthesis and analysis of substrate analogues for UDP-galactopyranose mutase: implication for an oxocarbenium ion intermediate in the catalytic mechanism.Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.Identification of novel mutations in the human HPRT gene.Phenotypic variation among seven members of one family with deficiency of hypoxanthine-guanine phosphoribosyltransferase.A point mutation at the subunit interface of hypoxanthine-guanine-xanthine phosphoribosyltransferase impairs activity: role of oligomerization in catalysis.Kinetic studies of the uracil phosphoribosyltransferase reaction catalyzed by the Bacillus subtilis pyrimidine attenuation regulatory protein PyrR.Lesch-Nyhan disease in two families from Chiloé Island with mutations in the HPRT1 gene.Mutation in the Human HPRT1 Gene and the Lesch-Nyhan Syndrome.Human HPRT1 gene and the Lesch-Nyhan disease: Substitution of alanine for glycine and inversely in the HGprt enzyme protein.
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P2860
The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The 2.0 A structure of human h ...... nsition-state analog inhibitor
@ast
The 2.0 A structure of human h ...... nsition-state analog inhibitor
@en
The 2.0 A structure of human h ...... nsition-state analog inhibitor
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The 2.0 A structure of human h ...... nsition-state analog inhibitor
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type
label
The 2.0 A structure of human h ...... nsition-state analog inhibitor
@ast
The 2.0 A structure of human h ...... nsition-state analog inhibitor
@en
The 2.0 A structure of human h ...... nsition-state analog inhibitor
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The 2.0 A structure of human h ...... nsition-state analog inhibitor
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prefLabel
The 2.0 A structure of human h ...... nsition-state analog inhibitor
@ast
The 2.0 A structure of human h ...... nsition-state analog inhibitor
@en
The 2.0 A structure of human h ...... nsition-state analog inhibitor
@en-gb
The 2.0 A structure of human h ...... nsition-state analog inhibitor
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P921
P3181
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P1476
The 2.0 A structure of human h ...... nsition-state analog inhibitor
@en
P2093
C Grubmeyer
R H Furneaux
V L Schramm
P2888
P304
P3181
P356
10.1038/9376
P407
P577
1999-06-01T00:00:00Z
P5875
P6179
1002922123