Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock
about
The distribution of fitness effects of new deleterious amino acid mutations in humansInferring the distribution of mutational effects on fitness in DrosophilaAn integrated view of protein evolutionRelaxation of selective constraint on dog mitochondrial DNA following domesticationQuantifying the threat of extinction from Muller's ratchet in the diploid Amazon molly (Poecilia formosa)Mitigating mutational meltdown in mammalian mitochondria.Assessing the evolutionary impact of amino acid mutations in the human genome.Measuring the rates of spontaneous mutation from deep and large-scale polymorphism dataStanding variation and new mutations both contribute to a fast response to selection for flowering time in maize inbreds.What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?Determining the factors driving selective effects of new nonsynonymous mutations.Shifts in the intensity of purifying selection: an analysis of genome-wide polymorphism data from two closely related yeast species.Background selection as baseline for nucleotide variation across the Drosophila genome.Purifying selection in deeply conserved human enhancers is more consistent than in coding sequences.Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. mirandaA population genetics-phylogenetics approach to inferring natural selection in coding sequencesDetecting positive selection within genomes: the problem of biased gene conversion.Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.Estimating selection on nonsynonymous mutationsLinkage disequilibrium as a signature of selective sweepsThe effects of linkage on comparative estimators of selection.Causes of natural variation in fitness: evidence from studies of Drosophila populations.Approximation to the distribution of fitness effects across functional categories in human segregating polymorphisms.A method for inferring the rate of occurrence and fitness effects of advantageous mutationsTissue-driven hypothesis of genomic evolution and sequence-expression correlations.Adaptations to fluctuating selection in DrosophilaThe other side of the nearly neutral theory, evidence of slightly advantageous back-mutations.Dynamic changes in translational efficiency are deduced from codon usage of the transcriptomePatterns of molecular evolution in Caenorhabditis preclude ancient origins of selfing.The polymorphism frequency spectrum of finitely many sites under selectionQuantifying dominance and deleterious effect on human disease genes.Molecular population genomics: a short history.Mining the pig genome to investigate the domestication process.DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA.A comparison of models to infer the distribution of fitness effects of new mutations.Estimating the prevalence of functional exonic splice regulatory information.A coarse-grained biophysical model of sequence evolution and the population size dependence of the speciation rate.Evolutionary framework for protein sequence evolution and gene pleiotropy.Estimating the genomewide rate of adaptive protein evolution in DrosophilaPleiotropy can be effectively estimated without counting phenotypes through the rank of a genotype-phenotype map.
P2860
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P2860
Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Estimating the distribution of ...... ations for the molecular clock
@ast
Estimating the distribution of ...... ations for the molecular clock
@en
Estimating the distribution of ...... ations for the molecular clock
@en-gb
Estimating the distribution of ...... ations for the molecular clock
@nl
type
label
Estimating the distribution of ...... ations for the molecular clock
@ast
Estimating the distribution of ...... ations for the molecular clock
@en
Estimating the distribution of ...... ations for the molecular clock
@en-gb
Estimating the distribution of ...... ations for the molecular clock
@nl
prefLabel
Estimating the distribution of ...... ations for the molecular clock
@ast
Estimating the distribution of ...... ations for the molecular clock
@en
Estimating the distribution of ...... ations for the molecular clock
@en-gb
Estimating the distribution of ...... ations for the molecular clock
@nl
P2860
P356
P1476
Estimating the distribution of ...... ations for the molecular clock
@en
P2093
Gwenaël Piganeau
P2860
P304
10335-10340
P356
10.1073/PNAS.1833064100
P407
P577
2003-08-18T00:00:00Z