Medicinal Chemistry Based on the Sugar Code: Fundamentals of Lectinology and Experimental Strategies with Lectins as Targets
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Protein-carbohydrate interactions studied by NMR: from molecular recognition to drug designA Lectin from Platypodium elegans with Unusual Specificity and Affinity for Asymmetric Complex N-GlycansNMR investigations of protein-carbohydrate interactions binding studies and refined three-dimensional solution structure of the complex between the B domain of wheat germ agglutinin and N,N', N"-triacetylchitotriose.Detection of ligand- and solvent-induced shape alterations of cell-growth-regulatory human lectin galectin-1 in solution by small angle neutron and x-ray scattering.Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo.Glycohistochemistry: the why and how of detection and localization of endogenous lectins.Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease.Small angle neutron scattering as sensitive tool to detect ligand-dependent shape changes in a plant lectin with beta-trefoil folding and their dependence on the nature of the solvent.On the importance of carbohydrate-aromatic interactions for the molecular recognition of oligosaccharides by proteins: NMR studies of the structure and binding affinity of AcAMP2-like peptides with non-natural naphthyl and fluoroaromatic residues.A simple approach to well-defined sugar-coated surfaces for interaction studies.Lectin histochemical investigations of the distal gut of chicks with special emphasis on the follicle-associated epithelium.Introduction of extended LEC14-type branching into core-fucosylated biantennary N-glycan.NMR and modeling studies of protein-carbohydrate interactions: synthesis, three-dimensional structure, and recognition properties of a minimum hevein domain with binding affinity for chitooligosaccharides.First demonstration of differential inhibition of lectin binding by synthetic tri- and tetravalent glycoclusters from cross-coupling of rigidified 2-propynyl lactoside.Lectin-based drug design: combined strategy to identify lead compounds using STD NMR spectroscopy, solid-phase assays and cell binding for a plant toxin model.Toward functional glycomics by localization of tissue lectins: immunohistochemical galectin fingerprinting during diethylstilbestrol-induced kidney tumorigenesis in male Syrian hamster.Glycobiology, how to sugar-coat an undergraduate advanced biochemistry laboratory.Phosphorylated human lectin galectin-3: analysis of ligand binding by histochemical monitoring of normal/malignant squamous epithelia and by isothermal titration calorimetry.Identification and characterization of a novel legume-like lectin cDNA sequence from the red marine algae Gracilaria fisheri.Glucocorticoid-induced differential expression of the sialylated and nonsialylated Lewis(a) epitopes and respective binding sites in human nasal polyps maintained under ex vivo tissue culture conditions.Relative amounts of sialic acid and fucose of amniotic fluid glycoconjugates in relation to pregnancy age.Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery.Synthesis of Mannose-6-Phosphate Analogues and their Utility as Angiogenesis RegulatorsFluorinated Carbohydrates as Lectin Ligands: Biorelevant Sensors with Capacity to Monitor Anomer Affinity in 19F-NMR-Based Inhibitor Screening
P2860
Q26849619-7AF8F174-C01B-43EA-80B5-EEDD989DB479Q27681146-8876472F-3BD9-4E44-9E9A-D605CDC5F9EDQ30598951-8755AC4D-8574-438B-AC53-A5382BD4853BQ30807427-83D774E0-2741-4772-AB61-E1D162BE9AF7Q31033747-085DE7D7-F1CE-468B-BA7A-7C485B419D64Q34205805-B3CDDE02-CD71-4D64-B2F9-A8541E8D64F4Q36657924-27BF15BB-578D-47DF-AE0D-78EF8262327CQ38289351-93D39E67-72CB-43E9-9E97-FD2110CE1A34Q38320004-AB9978E4-26EE-4ED6-87DA-93BBAE650F9EQ38321438-4B06D26E-816C-4401-B331-735D18831AC9Q38327863-5885ABD1-0E4C-4ED8-985E-F254B3084BEEQ38328250-66C1A8A1-A0EC-4CC4-81E4-5AFBF826A2E3Q38336670-D8783D32-D940-41C7-97BE-836B000404E7Q38347052-E34BFF38-1A6A-41FB-A946-BA4E341F0665Q38347059-DE88E76D-BC66-4B5B-AE0F-A3DA5BE2E427Q38489924-AEFCA150-DEC8-438C-9E91-8B51F2FB3E99Q40292868-7721C71F-B48F-416D-A468-CA4DD6538191Q42444325-840866C8-0F96-40DC-BD60-27E9F5295F4FQ42626444-6B1ACC43-B35B-4CB8-A4D5-4CA014EE2CA0Q44259827-0F148521-C2C5-4527-8CCB-B5C2C9F9ADA0Q46823602-F011F3A8-2C3B-4E9D-98E3-9D19765E6EF4Q55223335-C5BA075C-3DAD-406B-88FA-F53F58632E26Q56524466-67A6C870-8B95-42CA-9611-772AAE3CB5BFQ58036016-75544F75-6143-424B-987A-F11471CCD4D6
P2860
Medicinal Chemistry Based on the Sugar Code: Fundamentals of Lectinology and Experimental Strategies with Lectins as Targets
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2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@ast
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@en
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@en-gb
type
label
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@ast
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@en
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@en-gb
prefLabel
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@ast
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@en
Medicinal Chemistry Based on t ...... tegies with Lectins as Targets
@en-gb
P2093
P356
P1476
Medicinal chemistry based on t ...... tegies with lectins as targets
@en
P2093
C W von der Lieth
H C Siebert
J Jiménez-Barbero
T Diaz-Mariño
P304
P356
10.2174/0929867003375164
P577
2000-04-01T00:00:00Z