Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins
about
Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridgeDynamic regulation of p53 subnuclear localization and senescence by MORC3Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complexA conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidaseHuman PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteinsPIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.Biosynthesis and deficiencies of glycosylphosphatidylinositolGWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast.The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p.PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols.Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteinsTranscriptome and biochemical analysis reveals that suppression of GPI-anchor synthesis leads to autophagy and possible necroptosis in Aspergillus fumigatusRequirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositolRole of Herp in the endoplasmic reticulum stress responsePost-translational GPI lipid anchor modification of proteins in kingdoms of life: analysis of protein sequence data from complete genomes.Molecular switching system using glycosylphosphatidylinositol to select cells highly expressing recombinant proteinsEarly events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p.Transamidase subunit GAA1/GPAA1 is a M28 family metallo-peptide-synthetase that catalyzes the peptide bond formation between the substrate protein's omega-site and the GPI lipid anchor's phosphoethanolamine.Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling.Mutational analysis of the glycosylphosphatidylinositol (GPI) anchor pathway demonstrates that GPI-anchored proteins are required for cell wall biogenesis and normal hyphal growth in Neurospora crassa.Profiling the expression pattern of GPI transamidase complex subunits in human cancer.Protein Glycosylation in Aspergillus fumigatus Is Essential for Cell Wall Synthesis and Serves as a Promising Model of Multicellular Eukaryotic Development.GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunitsGlycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sicknessProteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma.Alterations of GPI transamidase subunits in head and neck squamous carcinoma.Architecture and biosynthesis of the Saccharomyces cerevisiae cell wall.Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review].Low-resolution structure of the soluble domain GPAA1 (yGPAA170-247) of the glycosylphosphatidylinositol transamidase subunit GPAA1 from Saccharomyces cerevisiaeThematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids.Trypanosome glycosylphosphatidylinositol biosynthesis.Methods to study GPI anchoring of proteins.Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT).GPI transamidase and GPI anchored proteins: oncogenes and biomarkers for cancer.Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin.A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q24.3.Identification of a novel functional specificity signal within the GPI anchor signal sequence of carcinoembryonic antigen.
P2860
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P2860
Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@ast
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@en
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@en-gb
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@nl
type
label
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@ast
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@en
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@en-gb
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@nl
prefLabel
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@ast
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@en
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@en-gb
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@nl
P2093
P2860
P356
P1476
Gaa1p and gpi8p are components ...... attachment of GPI to proteins
@en
P2093
P2860
P304
P356
10.1091/MBC.11.5.1523
P407
P577
2000-05-01T00:00:00Z