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Structure and functionality in flavivirus NS-proteins: perspectives for drug design

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

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The role of viral persistence in flavivirus biology Structure-guided insights on the role of NS1 in flavivirus infection ZIKA-How fast does this virus mutate?Zika virus – emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives – a comprehensive review Transcriptome Analysis Reveals a Signature Profile for Tick-Borne Flavivirus Persistence in HEK 293T Cells Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase Understanding the dengue viruses and progress towards their control Synergistic interactions between the NS3(hel) and E proteins contribute to the virulence of dengue virus type 1 Illustrating and homology modeling the proteins of the Zika virus.A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication Virtual Screening for Potential Inhibitors of NS3 Protein of Zika Virus Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target The Zika virus methyltransferase: structure and functions for drug design perspectives Zika virus: from pathogenesis to disease control In vitro reconstitution of SARS-coronavirus mRNA cap methylation The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase Dengue and Zika viruses: lessons learned from the similarities between these Aedes mosquito-vectored arboviruses Future developments in biosensors for field-ready Zika virus diagnostics Analysis of Ribonucleotide 5’ -Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-dependent RNA Polymerase Using Non-Radioactive Polymerase Assays Inhibitors compounds of the flavivirus replication process Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein.Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis.Zika virus: An emerging flavivirus.Biological and historical overview of Zika virus Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses.Steady-state NTPase activity of Dengue virus NS3: number of catalytic sites, nucleotide specificity and activation by ssRNA.Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus.Exploring of primate models of tick-borne flaviviruses infection for evaluation of vaccines and drugs efficacy.A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines.Biocrystallography: past, present, future.Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug.Monomeric nature of dengue virus NS3 helicase and thermodynamic analysis of the interaction with single-stranded RNA.Molecular basis for nucleotide conservation at the ends of the dengue virus genome.Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication

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P2860

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

http://www.wikidata.org/entity/Q23011530

description

2010 nî lūn-bûn

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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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J.ANTIVIRAL.2009.11.009

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Antiviral Research

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Structure and functionality in flavivirus NS-proteins: perspectives for drug design

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Anna M Jansson

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Cécile Baronti

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Ernest A Gould

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Grégory Moureau

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Holger Steuber

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Jonathan M Grimes

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Raymond J Owens

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Shelley Cook

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P2860

Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses

A 5' RNA element promotes dengue virus RNA synthesis on a circular genome

Population dynamics of flaviviruses revealed by molecular phylogenies

Molecular biology of flaviviruses

A New Flavivirus and a New Vector: Characterization of a Novel Flavivirus Isolated from Uranotaenia Mosquitoes from a Tropical Rain Forest

Biological Transmission of Arboviruses: Reexamination of and New Insights into Components, Mechanisms, and Unique Traits as Well as Their Evolutionary Trends

Helicase structure and mechanism

Phylogeny of the genus Flavivirus

Genomics and evolution of Aedes-borne flaviviruses

Genome sequencing in microfabricated high-density picolitre reactors

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125-48

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10.1016/J.ANTIVIRAL.2009.11.009

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2

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David Ian Stuart

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Barbara Selisko

Xavier de Lamballerie

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Michela Bollati

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2010-08-01T00:00:00Z

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19945487

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