Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model
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The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection ModelExtended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever PatientsNonstructural Proteins Are Preferential Positive Selection Targets in Zika Virus and Related FlavivirusesMouse models to study dengue virus immunology and pathogenesisDengue: an update on treatment optionsDifferential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylationSulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical applicationBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondPathogenesis and Inhibition of Flaviviruses from a Carbohydrate Perspective18F-FDG as an inflammation biomarker for imaging dengue virus infection and treatment responseCurrent Status of Dengue Therapeutics Research and Development.Novel approaches to flavivirus drug discovery.Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses.The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replicationDengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice.The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model.Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.Flaviviruses are sensitive to inhibition of thymidine synthesis pathwaysThree-Month Real-Time Dengue Forecast Models: An Early Warning System for Outbreak Alerts and Policy Decision Support in Singapore.Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.Imino sugar glucosidase inhibitors as broadly active anti-filovirus agentsTargeting host factors to treat West Nile and dengue viral infections.West Nile virus drug discovery.Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.Drugs for dengue: a patent review (2010-2014).Antiviral drug discovery: broad-spectrum drugs from nature.Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase : synthesis, structure-activity relationship studies and antiviral activity.Effect of modulation of unfolded protein response pathway on dengue virus infection.Investigational drugs in early development for treating dengue infection.Repurposing of prochlorperazine for use against dengue virus infection.A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.The role of the unfolded protein response in dengue virus pathogenesis.Structural biology. Unraveling a flavivirus enigma.Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.Dengue-Virus-InfektionenDengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidateFlaviviral regulation of the unfolded protein response: can stress be beneficial?
P2860
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P2860
Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@ast
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@en
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@en-gb
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@nl
type
label
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@ast
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@en
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@en-gb
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@nl
prefLabel
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@ast
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@en
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@en-gb
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@nl
P2093
P3181
P1433
P1476
Celgosivir treatment misfolds ...... t lethal challenge mouse model
@en
P2093
Abhay P.S. Rathore
Cynthia Sung
John E. Connolly
Prasad N. Paradkar
Satoru Watanabe
Subhash G. Vasudevan
P304
P3181
P356
10.1016/J.ANTIVIRAL.2011.10.002
P407
P577
2011-12-01T00:00:00Z