Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling
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Phosphoinositides: tiny lipids with giant impact on cell regulationA Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell DevelopmentGeneral and Versatile Autoinhibition of PLC IsozymesRac Regulates Its Effector Phospholipase C 2 through Interaction with a Split Pleckstrin Homology DomainA crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activationRole of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein.Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker regionIntramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain.SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITKBCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.Calcium signalling and cell-fate choice in B cells.Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesisAutoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha.Syk and pTyr'd: Signaling through the B cell antigen receptorMechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.Ibrutinib and novel BTK inhibitors in clinical development.A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.Membrane environment exerts an important influence on rac-mediated activation of phospholipase Cγ2.Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway.Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases.Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.Nuclear envelope assembly is promoted by phosphoinositide-specific phospholipase C with selective recruitment of phosphatidylinositol-enriched membranes.Antigen activates B Cell Receptor (BCR) leading to generation of second messengersSignalosomes assemble at the activated BCRp-Y753;Y759-PLCG2 translocates from cytosol to plasma membranePLCG2 translocates from cytosol to plasma membranePhosphorylated BTK phosphorylates PLCG2
P2860
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P2860
Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling
description
2001 nî lūn-bûn
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2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2001年の論文
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年學術文章
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Tyrosine residues in phospholi ...... e function in B-cell signaling
@ast
Tyrosine residues in phospholi ...... e function in B-cell signaling
@en
Tyrosine residues in phospholi ...... e function in B-cell signaling
@en-gb
Tyrosine residues in phospholi ...... e function in B-cell signaling
@nl
type
label
Tyrosine residues in phospholi ...... e function in B-cell signaling
@ast
Tyrosine residues in phospholi ...... e function in B-cell signaling
@en
Tyrosine residues in phospholi ...... e function in B-cell signaling
@en-gb
Tyrosine residues in phospholi ...... e function in B-cell signaling
@nl
prefLabel
Tyrosine residues in phospholi ...... e function in B-cell signaling
@ast
Tyrosine residues in phospholi ...... e function in B-cell signaling
@en
Tyrosine residues in phospholi ...... e function in B-cell signaling
@en-gb
Tyrosine residues in phospholi ...... e function in B-cell signaling
@nl
P2093
P2860
P921
P356
P1476
Tyrosine residues in phospholi ...... e function in B-cell signaling
@en
P2093
R L Williams
R Rodriguez
P2860
P304
P356
10.1074/JBC.M107577200
P407
P577
2001-12-21T00:00:00Z