Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity
about
Activation of Arp2/3 complex: addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp2p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrateDirect regulation of Arp2/3 complex activity and function by the actin binding protein coroninComparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasitesPI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.The Entamoeba histolytica, Arp2/3 Complex Is Recruited to Phagocytic Cups through an Atypical Kinase EhAK1Structure and Biochemical Properties of Fission Yeast Arp2/3 Complex Lacking the Arp2 SubunitARPC1/Arc40 mediates the interaction of the actin-related protein 2 and 3 complex with Wiskott-Aldrich syndrome protein family activators.Control of polarized assembly of actin filaments in cell motilityPhosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activationOrganization of the Arp2/3 complex in hippocampal spinesA subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complexDefining coarse-grained representations of large biomolecules and biomolecular complexes from elastic network models.Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and functionFilopodia formation in the absence of functional WAVE- and Arp2/3-complexes.Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing.An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability.Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assemblyThe Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunitPeering deeply inside the branch.The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleationDissecting regulatory networks of filopodia formation in a Drosophila growth cone modelEffect of high intratesticular estrogen on global gene expression and testicular cell number in rats.The structural basis of actin filament branching by the Arp2/3 complex.Molecular dynamics simulations of Arp2/3 complex activation.Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites.Extending the Arp2/3 complex and its regulation beyond the leading edgeCapping protein and the Arp2/3 complex regulate nonbundle actin filament assembly to indirectly control actin bundle positioning during Drosophila melanogaster bristle developmentNovel identification of Dermacentor variabilis Arp2/3 complex and its role in rickettsial infection of the arthropod vector.p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb.Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.Genome-Wide siRNA Screen Identifies Complementary Signaling Pathways Involved in Listeria Infection and Reveals Different Actin Nucleation Mechanisms during Listeria Cell Invasion and Actin Comet Tail FormationSignalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestineThe Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.Lecithin Prevents Cortical Cytoskeleton Reorganization in Rat Soleus Muscle Fibers under Short-Term Gravitational Disuse.Key structural features of the actin filament Arp2/3 complex branch junction revealed by molecular simulation.The conformational state of actin filaments regulates branching by actin-related protein 2/3 (Arp2/3) complex.Molecular requirements for actin-based lamella formation in Drosophila S2 cellsInsertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex.
P2860
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P2860
Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Reconstitution of human Arp2/3 ...... complex structure and activity
@ast
Reconstitution of human Arp2/3 ...... complex structure and activity
@en
Reconstitution of human Arp2/3 ...... complex structure and activity
@en-gb
Reconstitution of human Arp2/3 ...... complex structure and activity
@nl
type
label
Reconstitution of human Arp2/3 ...... complex structure and activity
@ast
Reconstitution of human Arp2/3 ...... complex structure and activity
@en
Reconstitution of human Arp2/3 ...... complex structure and activity
@en-gb
Reconstitution of human Arp2/3 ...... complex structure and activity
@nl
prefLabel
Reconstitution of human Arp2/3 ...... complex structure and activity
@ast
Reconstitution of human Arp2/3 ...... complex structure and activity
@en
Reconstitution of human Arp2/3 ...... complex structure and activity
@en-gb
Reconstitution of human Arp2/3 ...... complex structure and activity
@nl
P2093
P921
P3181
P1433
P1476
Reconstitution of human Arp2/3 ...... complex structure and activity
@en
P2093
H Gournier
H Niederstrasser
P304
P3181
P356
10.1016/S1097-2765(01)00393-8
P407
P50
P577
2001-11-01T00:00:00Z