PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
about
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and functionThe MafA transcription factor appears to be responsible for tissue-specific expression of insulinFoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start siteAryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetesPAX6 mutations: genotype-phenotype correlationsNeonatal diabetes: an expanding list of genes allows for improved diagnosis and treatmentSequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergencesMembers of the large Maf transcription family regulate insulin gene transcription in islet beta cellsPax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretionThe transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult miceMany faces of monogenic diabetesThe activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human corneal limbus3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genesPAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation.Wnt signaling in caudal dysgenesis and diabetic embryopathy.Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreasMinireview: microRNA function in pancreatic β cells.Development and diseases of the pancreas.PAX6 and congenital eye malformations.The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye developmentConserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expressionPtf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.Diabetic nephropathy and anaemia.Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia.Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.Inactivation of specific β cell transcription factors in type 2 diabetes.PAX6 maintains β cell identity by repressing genes of alternative islet cell types.A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors.Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets.In vitro effects of mycophenolic acid on survival, function, and gene expression of pancreatic beta-cells.Microphthalmia transcription factor regulates pancreatic β-cell function.In vitro differentiation of adipose-tissue-derived mesenchymal stem cells into neural retinal cells through expression of human PAX6 (5a) gene.Cross-species microarray analysis with the OSCAR system suggests an INSR->Pax6->NQO1 neuro-protective pathway in aging and Alzheimer's disease.Identification of a novel PDX-1 binding site in the human insulin gene enhancer.Case of aniridia with a heterozygous PAX6 mutation in which the glucagon response to arginine was evaluated.The effect of haplotype variation in the bovine PAX6 gene.Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat.
P2860
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P2860
PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2002 թվականի հունվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
@en-gb
PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
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P2093
P921
P1433
P1476
PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
@en
P2093
Masatsugu Hori
Munehide Matsuhisa
Shin-ichi Gorogawa
Shuji Yamamoto
Takao Watarai
Tetsuyuki Yasuda
Yasuaki Kuwayama
Yasuo Tano
Yoshimitsu Yamasaki
Yoshio Fujitani
P304
P356
10.2337/DIABETES.51.1.224
P407
P577
2002-01-01T00:00:00Z