Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer
about
Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitisRetinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamilyCrystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cellsElevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stressKnockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cellsModulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells.The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer.Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism.AKR1C3 overexpression mediates methotrexate resistance in choriocarcinoma cellsSelective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment libraryRole of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolismInhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.The aldo-keto reductases (AKRs): Overview.Role of aldo-keto reductase enzymes in mediating the timing of parturitionPromiscuity and diversity in 3-ketosteroid reductases.Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride.Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma.Alterations in estrogen signalling pathways upon acquisition of anthracycline resistance in breast tumor cellsThe roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell deathModification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function.The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial CancerPyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents.Transcript level of AKR1C3 is down-regulated in gastric cancer.Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival.The role of aldo-keto reductase 1C3 (AKR1C3)-mediated prostaglandin D2 (PGD2) metabolism in keloids.Identification of genes associated with castration‑resistant prostate cancer by gene expression profile analysis.Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis.Simvastatin in combination with meclofenamic acid inhibits the proliferation and migration of human prostate cancer PC-3 cells via an AKR1C3 mechanism.
P2860
Q24299872-5EE9BEE1-6942-442A-96B2-25ADF7CC2602Q24323295-505EE35F-51ED-459B-8CE8-879DCE63DB6AQ27671816-3BCBD021-A2B3-4B19-B0F1-593ADE01E01CQ28544009-C7D9DE28-4251-4C7A-9AEF-89AC130CFE8CQ28545132-CFC81295-E2DA-4577-8690-24BD30E6502CQ33563699-03ECBC25-B247-42D8-998A-70A9CA47AA63Q33645120-A4413E81-123B-4FF2-B13D-3E9D85FD848EQ33770742-0924D08F-EDA9-47DC-91FD-BDAFF7DD839DQ34016727-F93AED78-B0FD-4A76-81B6-C33D2905E3F1Q34102024-C9BF4E4A-0968-4843-A9C4-C182B423287EQ34375275-80D85DC5-2BEF-48D9-BC2A-96C54E229530Q34382405-9D27ADBC-105D-43DD-A1C8-71ECE36AA8BDQ34618859-B6DF673C-7B06-4709-B3BF-8D147441B3A4Q35305934-235DCE96-2891-4BD5-B060-9DA66B4F78BBQ35660367-3C1F0EF9-4CCB-4F7A-A602-89257F9D74A1Q35691232-533B47A6-C67B-429E-A264-2B50C9517D5AQ35825211-3E8FF022-4103-4D09-A661-F0F77ABC64BDQ35869909-10FBE602-8E95-4033-B4C2-7E8570E85D72Q36003283-9A5B892E-071B-4D6F-9A5E-164C5D90AD13Q36280127-E1AC85D8-B518-4AEB-945E-B97AA84EC4F7Q37225331-79BC15D5-DD6C-4B8A-A00C-1A35FDE5D51BQ38118666-068F2151-3A3B-4CC8-BA09-2CCBE7EB562EQ38687447-B658DD4B-B1C6-4837-B7AF-8B7030EF5794Q38760811-D207F0D6-23F7-428A-8C39-00B1959EA468Q38782882-124ACC6B-DD9B-4D46-A0C3-2880F17F36AEQ40124162-DF3FFEC9-0A0B-4F43-9EFC-C78C1E7CE3F3Q40606502-D81F9AB7-F32B-442E-8EC0-63148757EA05Q47811759-0BD3253A-0C91-4BB3-A4D7-9769FCB23BC0Q47818730-16E92470-DEFD-407D-97E2-32529445C406Q48251191-598C808E-8782-4EDE-BD1E-2BFF41AEA9C2Q50053255-8A228048-5D87-45DF-8F9B-2315E6E8190C
P2860
Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@ast
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@en
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@en-gb
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@nl
type
label
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@ast
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@en
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@en-gb
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@nl
prefLabel
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@ast
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@en
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@en-gb
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@nl
P2093
P2860
P921
P1476
Aldo-keto reductase 1C3 expres ...... er-expression in breast cancer
@en
P2093
Ian A Blair
Michael C Byrns
Seon Hwa Lee
Trevor M Penning
P2860
P304
P356
10.1016/J.JSBMB.2009.12.009
P407
P577
2010-02-15T00:00:00Z