The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity
about
Ten years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinicHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsUnique functional and structural properties of the LRRK2 protein ATP-binding pocket.LRRK2 autophosphorylation enhances its GTPase activityDecoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.LRRK2 pathobiology in Parkinson's disease.Cellular processes associated with LRRK2 function and dysfunctionLRRK2 Pathways Leading to Neurodegeneration.Mechanisms of Mutant LRRK2 Neurodegeneration.Molecular Insights and Functional Implication of LRRK2 Dimerization.LRRK2 Phosphorylation.LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review.
P2860
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P2860
The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The Parkinson disease-linked L ...... g to increased kinase activity
@ast
The Parkinson disease-linked L ...... g to increased kinase activity
@en
The Parkinson disease-linked L ...... g to increased kinase activity
@en-gb
The Parkinson disease-linked L ...... g to increased kinase activity
@nl
type
label
The Parkinson disease-linked L ...... g to increased kinase activity
@ast
The Parkinson disease-linked L ...... g to increased kinase activity
@en
The Parkinson disease-linked L ...... g to increased kinase activity
@en-gb
The Parkinson disease-linked L ...... g to increased kinase activity
@nl
prefLabel
The Parkinson disease-linked L ...... g to increased kinase activity
@ast
The Parkinson disease-linked L ...... g to increased kinase activity
@en
The Parkinson disease-linked L ...... g to increased kinase activity
@en-gb
The Parkinson disease-linked L ...... g to increased kinase activity
@nl
P2093
P2860
P921
P3181
P356
P1476
The Parkinson disease-linked L ...... g to increased kinase activity
@en
P2093
Marcie A Glicksman
Regina Lin
Samantha Bender
Soumya Ray
Stephanie Kang
P2860
P304
P3181
P356
10.1074/JBC.M113.537811
P407
P577
2014-05-09T00:00:00Z