Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels
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Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cellsFunny channel gene mutations associated with arrhythmiasCanine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and TreatmentLigand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMPStructure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channelStructures of the Human HCN1 Hyperpolarization-Activated ChannelA reduced mechanical model for cAMP-modulated gating in HCN channelsDouble electron-electron resonance reveals cAMP-induced conformational change in HCN channels.Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channelsFamily of prokaryote cyclic nucleotide-modulated ion channelsStructural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy.An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels.Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMPConformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides.Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.Cannabinoid Control of Learning and Memory through HCN ChannelsA secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channelsFlavonoid regulation of HCN2 channels.Structure and dynamics underlying elementary ligand binding events in human pacemaking channelsA KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.Mechanism of electromechanical coupling in voltage-gated potassium channels.Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytesNot very funny: how a single mutation causes heritable bradycardia.Rates and equilibrium constants of the ligand-induced conformational transition of an HCN ion channel protein domain determined by DEER spectroscopy.HCN Channels Modulators: The Need for Selectivity.HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels.Structure of a eukaryotic cyclic-nucleotide-gated channel.A leucine zipper motif essential for gating of hyperpolarization-activated channels.Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance.Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardiaThe intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation.Elementary functional properties of single HCN2 channels.CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel.Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.Characterization of a cyclic nucleotide-activated K(+) channel and its lipid environment by using solid-state NMR spectroscopy.
P2860
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P2860
Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@ast
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@en
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@en-gb
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@nl
type
label
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@ast
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@en
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@en-gb
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@nl
altLabel
Tetramerization Dynamics of C- ...... clic Nucleotide-gated Channels
@en
prefLabel
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@ast
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@en
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@en-gb
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@nl
P2093
P2860
P50
P921
P356
P1476
Tetramerization dynamics of C- ...... clic nucleotide-gated channels
@en
P2093
Holger Martin
Jay A Bertrand
Marina Fasolini
Stefan Möller
P2860
P304
P356
10.1074/JBC.M111.297606
P407
P50
P577
2011-12-30T00:00:00Z