The POT1-TPP1 telomere complex is a telomerase processivity factor
about
Diminished telomeric 3' overhangs are associated with telomere dysfunction in Hoyeraal-Hreidarsson syndromeHuman single-stranded DNA binding proteins are essential for maintaining genomic stabilityHOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitmentStructural basis of selective ubiquitination of TRF1 by SCFFbx4Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationConserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotesIn vivo stoichiometry of shelterin componentsIdentification of ATPases pontin and reptin as telomerase components essential for holoenzyme assemblyOB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulationTelomere protection by mammalian Pot1 requires interaction with Tpp1POT1 association with TRF2 regulates telomere lengthHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationA human telomerase holoenzyme protein required for Cajal body localization and telomere synthesisFinding the end: recruitment of telomerase to telomeresTIN2-tethered TPP1 recruits human telomerase to telomeres in vivoTelomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cellsProcessive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditionsSolution structure and dynamics of the wild-type pseudoknot of human telomerase RNATelomere protection by TPP1 is mediated by POT1a and POT1bStructure and function of the telomeric CST complexThe short and long telomere syndromes: paired paradigms for molecular medicineTelomeres-structure, function, and regulationMultiple facets of TPP1 in telomere maintenanceSingle-stranded DNA-binding proteins: multiple domains for multiple functionsTelomere capping proteins are structurally related to RPA with an additional telomere-specific domainStn1-Ten1 is an Rpa2-Rpa3-like complex at telomeresHow telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNAEffect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNACrystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complexCdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length RegulationStructural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase αStructurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNAA conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organismsAnalyses of Candida Cdc13 Orthologues Revealed a Novel OB Fold Dimer Arrangement, Dimerization-Assisted DNA Binding, and Substantial Structural Differences between Cdc13 and RPA70Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere MaintenanceStructure of Est3 reveals a bimodal surface with differential roles in telomere replicationProteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length.PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase.Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation.
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The POT1-TPP1 telomere complex is a telomerase processivity factor
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年論文
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2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The POT1-TPP1 telomere complex is a telomerase processivity factor
@ast
The POT1-TPP1 telomere complex is a telomerase processivity factor
@en
The POT1-TPP1 telomere complex is a telomerase processivity factor
@en-gb
The POT1-TPP1 telomere complex is a telomerase processivity factor
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type
label
The POT1-TPP1 telomere complex is a telomerase processivity factor
@ast
The POT1-TPP1 telomere complex is a telomerase processivity factor
@en
The POT1-TPP1 telomere complex is a telomerase processivity factor
@en-gb
The POT1-TPP1 telomere complex is a telomerase processivity factor
@nl
prefLabel
The POT1-TPP1 telomere complex is a telomerase processivity factor
@ast
The POT1-TPP1 telomere complex is a telomerase processivity factor
@en
The POT1-TPP1 telomere complex is a telomerase processivity factor
@en-gb
The POT1-TPP1 telomere complex is a telomerase processivity factor
@nl
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The POT1-TPP1 telomere complex is a telomerase processivity factor
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10.1038/NATURE05454
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2007-02-01T00:00:00Z
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1009193256