The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation
about
Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestinsThe structural basis for the negative regulation of thioredoxin by thioredoxin-interacting proteinA calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6.A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis.Structural basis for a novel interaction between TXNIP and Vav2Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate.Thioredoxin-interacting protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responsesDisruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity.Transcriptional and Translational Downregulation of Thioredoxin Interacting Protein Is Required for Metabolic Reprogramming during G(1).Thioredoxin regulates adipogenesis through thioredoxin-interacting protein (Txnip) protein stability.Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus.Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family.Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity.Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old MiceIdentification of Redox and Glucose-Dependent Txnip Protein InteractionsThioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation.TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment.Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms.An expanded family of arrestins regulate metabolism.Thioredoxin-interacting protein: pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes.Tyrosine phosphorylation of WW proteins.The E3 ligase Itch in immune regulation and beyond.Thioredoxin-interacting protein induced α-synuclein accumulation via inhibition of autophagic flux: Implications for Parkinson's disease.High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagyMutagenic analysis in a pure molecular system shows that thioredoxin-interacting protein residue Cys247 is necessary and sufficient for a mixed disulfide formation with thioredoxinHECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death.AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.Global identification of miR-373-regulated genes in breast cancer by quantitative proteomics.Hypoxia-inducible factor independent down-regulation of thioredoxin-interacting protein in hypoxia.Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cellsRecognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interactionTxnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice.K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)₂D₃: Is It Really the Vitamin D₃ Upregulated Protein?The Function of Thioredoxin-Binding Protein-2 (TBP-2) in Different Diseases.Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes
P2860
Q24305954-5AA3864C-929F-4CBB-9203-70F398297A21Q27681179-664A958B-B772-4678-AAA2-38F41CC86C79Q27936217-9C52008E-5C90-4878-9714-D6FC796AD84EQ27939281-068BCFAC-C093-4E24-9BAC-97FE062E4A25Q28116370-962AA42F-D2CA-4349-8ED4-07F91DFA4E53Q34056017-2B5CF381-5F93-4347-9E57-0C4F46AEB022Q34631988-D27B6310-5469-4A31-A2BE-7FEA1939AE1DQ34696555-F870D715-2258-4983-BE8E-33EF65D5DCB8Q34972559-87CD7B47-D792-4AEE-B187-9A779EFB156BQ35310007-DFBD7909-E53F-4701-A7A2-9626A53D07F5Q35634417-23BB68DB-E246-4B3B-9C07-FD1AD808F31DQ36228675-B112FC29-FA82-4269-BFBA-B8EFC3AFAAF7Q36629722-9A712809-E431-42F8-ABCB-F95E7C5A5C97Q36877602-B8D927E0-1FB0-4197-BA94-58A6AD76D1CAQ36954888-B94D0283-2FE7-44A6-A902-61101F26B566Q37089192-70921C34-864F-4283-BC17-573ABFE633CDQ37536634-F250D319-1E67-4CC7-8F8A-222026426588Q37648102-8DB04F39-EEC8-4499-81FF-EC2DD81091BFQ37935006-9063203D-B354-4E22-853A-F5C030D101FDQ38004211-1294101E-E6BF-453A-A173-FF5911E8A18CQ38236593-0B8773C4-AF78-4DA1-8475-7D0411695DB5Q38334839-71A7CB82-0768-43EC-AA7F-38CC5BF07022Q38530613-9A59A3F6-BFC5-430B-A92D-2AB6C78AC987Q38654031-C90BC2AF-E8E5-43E1-88F3-16F11F01FAD0Q38999747-D5D81629-A024-4DA0-B8B7-E3E3742E43DFQ39320319-ECB98C64-2A49-4FCE-8D5A-A53D7B55E338Q39456149-D7E259BF-4F73-45C6-ACCC-382ADF5C66F7Q39542812-2C7BFE6D-56C8-4EDF-8E5B-8F3147C5EE18Q39602023-169EC656-5C98-4929-8590-F0648402FC06Q39613970-D9EF496B-09A6-49A0-ADEA-DB74C5D761BAQ41026661-91921E28-5262-48B4-BD8A-CBC5310D575AQ42270113-497D098C-0665-41A8-8068-943B8D059F1FQ44112509-77EF15A3-1638-4C76-85EB-BB61DD35002DQ49596652-0C2170E5-F369-4482-893A-E8DF89E71EFCQ51740717-C4194BC5-2951-441E-9A5A-3A8D209AD995Q55185836-7C4B7164-32D0-4466-8746-DB5C767E2F85Q59127969-56116825-F78C-4431-8CA0-0284DAE67FCC
P2860
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@ast
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@en
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@en-gb
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@nl
type
label
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@ast
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@en
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@en-gb
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@nl
prefLabel
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@ast
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@en
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@en-gb
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@nl
P2093
P2860
P921
P3181
P356
P1476
The ubiquitin ligase itch regu ...... biquitin-dependent degradation
@en
P2093
Chenji Wang
Dejie Wang
Hongxiu Yu
P2860
P304
P3181
P356
10.1074/JBC.M109.063321
P407
P577
2010-03-19T00:00:00Z