The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding
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Serine racemase: a key player in apoptosis and necrosisThe crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug designCrystal structures of open and closed forms of d-serine deaminase from Salmonella typhimurium - implications on substrate specificity and catalysisCrystal Structure of Escherichia coli Diaminopropionate Ammonia-lyase Reveals Mechanism of Enzyme Activation and CatalysisStructural and Mutational Studies on Substrate Specificity and Catalysis of Salmonella typhimurium D-Cysteine DesulfhydraseModulating the function of human serine racemase and human serine dehydratase by protein engineeringRoles of quaternary structure and cysteine residues in the activity of human serine racemase.Cross-linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species.Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies.D-Serine Production, Degradation, and Transport in ALS: Critical Role of MethodologyControlling reaction specificity in pyridoxal phosphate enzymes.Serine racemase: an unconventional enzyme for an unconventional transmitter.Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.Exploiting racemases.Chemogenomics of pyridoxal 5'-phosphate dependent enzymes.Involvement of C-terminal amino acids of a hyperthermophilic serine racemase in its thermostability.ATP binding to human serine racemase is cooperative and modulated by glycine.Catalytic mechanism of serine racemase from Dictyostelium discoideum.Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target.Metal ion dependency of serine racemase from Dictyostelium discoideum.Identification of key amino acid residues in the catalytic mechanism of diaminopropionate ammonialyase from Salmonella typhimurium.Regulation of human serine racemase activity and dynamics by halides, ATP and malonateCrystal structure of maize serine racemase with pyridoxal 5'-phosphate.D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum.Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP.
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P2860
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding
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2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2010 թվականի ապրիլին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
The structure of mammalian ser ...... changes upon inhibitor binding
@ast
The structure of mammalian ser ...... changes upon inhibitor binding
@en
The structure of mammalian ser ...... changes upon inhibitor binding
@nl
type
label
The structure of mammalian ser ...... changes upon inhibitor binding
@ast
The structure of mammalian ser ...... changes upon inhibitor binding
@en
The structure of mammalian ser ...... changes upon inhibitor binding
@nl
altLabel
The Structure of Mammalian Ser ...... CHANGES UPON INHIBITOR BINDING
@en
prefLabel
The structure of mammalian ser ...... changes upon inhibitor binding
@ast
The structure of mammalian ser ...... changes upon inhibitor binding
@en
The structure of mammalian ser ...... changes upon inhibitor binding
@nl
P2093
P2860
P921
P356
P1476
The structure of mammalian ser ...... changes upon inhibitor binding
@en
P2093
Andrea Cesura
Andreas Ebneth
Brunella Felicetti
Dorian Schonfeld
Isabel Moraes
John Barker
Michael Wood
Myron A Smith
Owen Mather
Volker Mack
P2860
P304
P356
10.1074/JBC.M109.050062
P407
P577
2010-04-23T00:00:00Z