N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2
about
Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assaysA structure-guided approach for protein pocket modeling and affinity prediction.Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunctionSelectivity and potency of cyclin-dependent kinase inhibitors.Polyphony: superposition independent methods for ensemble-based drug discovery.Identification and Characterization of an Irreversible Inhibitor of CDK2.Structure-guided design of purine-based probes for selective Nek2 inhibitionChemistry and biology of multicomponent reactions.Parametrization of an Orbital-Based Linear-Scaling Quantum Force Field for Noncovalent Interactions.Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present.Sampling of conformational ensemble for virtual screening using molecular dynamics simulations and normal mode analysis.Identification by high-throughput screening of viridin analogs as biochemical and cell-based inhibitors of the cell cycle-regulated nek2 kinase.A computational study of the protein-ligand interactions in CDK2 inhibitors: using quantum mechanics/molecular mechanics interaction energy as a predictor of the biological activity.Role of interactions and volume variation in discriminating active and inactive forms of cyclin-dependent kinase-2 inhibitor complexes.Trifluoroethanol solvent facilitates selective N-7 methylation of purines.Combined venetoclax and alvocidib in acute myeloid leukemia.Molecular modelling on small molecular CDK2 inhibitors: an integrated approach using a combination of molecular docking, 3D-QSAR and pharmacophore modelling.Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.Synthesis and Biological Evaluation of N(2) -Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors.Synthesis of cycloalkyl substituted purine nucleosides via a metal-free radical route.
P2860
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P2860
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@ast
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@en
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@nl
type
label
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@ast
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@en
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@nl
prefLabel
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@ast
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@en
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@nl
P2093
P356
P1476
N2-substituted O6-cyclohexylme ...... clin-dependent kinases 1 and 2
@en
P2093
Ashleigh E Gibson
Bernard T Golding
Christine E Arris
David J Pratt
David R Newell
F Thomas Boyle
Hayley J Whitfield
Ian R Hardcastle
Jane A Endicott
Jerome Menyerol
P304
P356
10.1021/JM0311442
P407
P577
2004-07-15T00:00:00Z