Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
about
E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1)topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damageUbiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1Plk1-mediated phosphorylation of Topors regulates p53 stabilityIdentification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domainsTOPORS, implicated in retinal degeneration, is a cilia-centrosomal proteinCARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradationMolecular basis of Pirh2-mediated p53 ubiquitylationInflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1bMutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophyMechanisms, regulation and consequences of protein SUMOylationPolo-like kinase and its inhibitors: Ready for the match to start?Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivoIsolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitinationp53 ubiquitination: Mdm2 and beyondDeficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, ToporsNo Splicing, no dicing: non-proteolytic roles of the ubiquitin-proteasome system in transcription.Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replicationRegulatory functional territory of PLK-1 and their substrates beyond mitosis.Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics.Comprehensively surveying structure and function of RING domains from Drosophila melanogasterPolo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidyNeuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction.Limiting the power of p53 through the ubiquitin proteasome pathway.Making sense of ubiquitin ligases that regulate p53.Adipocyte morphology and implications for metabolic derangements in acquired obesity.Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors.Noninvasive diagnosis of acute cellular rejection in liver transplant recipients: a proteomic signature validated by enzyme-linked immunosorbent assayBack to your heart: ubiquitin proteasome system-regulated signal transductionTOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathwayUbiquitin proteolytic system: focus on SUMO.Meiosis in male Drosophila.Ubiquitin protein modification and signal transduction: implications for inflammatory bowel diseases.It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.p53 Regulation Goes Live-Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling.SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.The potential of proteasome inhibition in the treatment of colon cancer.
P2860
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P2860
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@ast
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@en
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@en-gb
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@nl
type
label
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@ast
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@en
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@en-gb
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@nl
prefLabel
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@ast
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@en
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@en-gb
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@nl
P2093
P2860
P921
P356
P1476
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
@en
P2093
Ahamed Saleem
Diptee Malegaonkar
Eric H Rubin
Henderson Marshall
James Brownell
Pooja Pungaliya
Rajeev Rajendra
Stuart Lutzker
Zeshaan Rasheed
P2860
P304
36440-36444
P356
10.1074/JBC.C400300200
P407
P50
P577
2004-07-09T00:00:00Z