A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
about
Crystallographic insight into collagen recognition by discoidin domain receptor 2Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivoCollagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1Candidate cell and matrix interaction domains on the collagen fibril, the predominant protein of vertebratesStructural basis of sequence-specific collagen recognition by SPARCThe NC2 Domain of Type IX Collagen Determines the Chain Register of the Triple HelixImplications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complexIdentification of platelet function defects by multi-parameter assessment of thrombus formationA General Shear-Dependent Model for Thrombus FormationSynergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood.First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processesEfficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member.Activated platelets from diabetic rats cause endothelial dysfunction by decreasing Akt/endothelial NO synthase signaling pathwayAegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin alpha2beta1, and von Willebrand factorPlatelet adhesion under flow.The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in strokeCollagen recognition and transmembrane signalling by discoidin domain receptorsRecombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor.Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes.Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.Identification of a major GpVI-binding locus in human type III collagen.Complex temporal changes in TGFβ oncogenic signaling drive thyroid carcinogenesis in a mouse modelStructural insights into the interactions between platelet receptors and fibrillar collagen.Synthesis and biological applications of collagen-model triple-helical peptides.Platelet biology and receptor pathways.On the versatility of von Willebrand factorThe collαgen III fibril has a "flexi-rod" structure of flexible sequences interspersed with rigid bioactive domains including two with hemostatic roles.The properties conferred upon triple-helical collagen-mimetic peptides by the presence of cysteine residues.Structural insight for chain selection and stagger control in collagen.A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream.Neutrophil granulocyte-dependent proteolysis enhances platelet adhesion to the arterial wall under high-shear flow.Identification of the active region responsible for the anti-thrombotic activity of anopheline anti-platelet protein from a malaria vector mosquito.Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril.Crafting of functional biomaterials by directed molecular self-assembly of triple helical peptide building blocks.Laboratory Testing for von Willebrand Factor Collagen Binding (VWF:CB).The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF
P2860
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P2860
A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A single high-affinity binding ...... thetic triple-helical peptides
@ast
A single high-affinity binding ...... thetic triple-helical peptides
@en
A single high-affinity binding ...... thetic triple-helical peptides
@nl
type
label
A single high-affinity binding ...... thetic triple-helical peptides
@ast
A single high-affinity binding ...... thetic triple-helical peptides
@en
A single high-affinity binding ...... thetic triple-helical peptides
@nl
prefLabel
A single high-affinity binding ...... thetic triple-helical peptides
@ast
A single high-affinity binding ...... thetic triple-helical peptides
@en
A single high-affinity binding ...... thetic triple-helical peptides
@nl
P2093
P1433
P1476
A single high-affinity binding ...... thetic triple-helical peptides
@en
P2093
Anthony R Peachey
Ben Maddox
Dafna Groeneveld
Eric G Huizinga
Nicolas Raynal
Philip G de Groot
Richard W Farndale
P304
P356
10.1182/BLOOD-2006-03-011965
P407
P50
P577
2006-08-15T00:00:00Z