Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
about
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutationsFuzziness: linking regulation to protein dynamicsThermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinityDirect inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signalingWnt/beta-catenin signaling and small molecule inhibitorsWnt/beta-catenin signaling: components, mechanisms, and diseasesWnt signaling: the good and the badAtomic model of human Rcd-1 reveals anarmadillo-like-repeat protein with in vitro nucleic acid binding propertiesCrystal Structure of a Full-Length β-CateninBiochemical and Structural Characterization of β-Catenin Interactions with Nonphosphorylated and CK2-Phosphorylated Lef-1Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signalingCasein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activityDesmosomes from a structural perspectivebeta-catenin destruction complex: insights and questions from a structural perspectiveThe β-catenin destruction complexMolecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signalingHuman APC sequesters β-catenin even in the absence of GSK-3β in a Drosophila modelInteractions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificityProtein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell linesdifferent Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coliNeurite outgrowth involves adenomatous polyposis coli protein and beta-cateninStructural basis for the recognition of Asef by adenomatous polyposis coli.Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesionHIV's Nef interacts with β-catenin of the Wnt signaling pathway in HEK293 cellsCharge environments around phosphorylation sites in proteins.Immunopurification of adenomatous polyposis coli (APC) proteins.Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry.A direct protein-protein interaction is involved in the suppression of beta-catenin transcription by retinoid X receptor alpha in colorectal cancer cells.Signaling from the adherens junction.GSK3: a multifaceted kinase in Wnt signaling.Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes.The evolutionary origin of epithelial cell-cell adhesion mechanismsCell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics.Wnt signalling pathway parameters for mammalian cellsNear-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway.Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex.Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.
P2860
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P2860
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@ast
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@en
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@en-gb
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@nl
type
label
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@ast
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@en
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@en-gb
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@nl
prefLabel
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@ast
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@en
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@en-gb
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@nl
P2093
P921
P1433
P1476
Mechanism of phosphorylation-d ...... le in beta-catenin degradation
@en
P2093
Hee-Jung Choi
Jennifer L Stamos
Nam-Chul Ha
P304
P356
10.1016/J.MOLCEL.2004.08.010
P407
P577
2004-08-27T00:00:00Z