Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
about
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutationsThermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinityWnt signaling: the good and the badNormal morphogenesis of epithelial tissues and progression of epithelial tumors.Crystal Structure of a Full-Length β-CateninBiochemical and Structural Characterization of β-Catenin Interactions with Nonphosphorylated and CK2-Phosphorylated Lef-1The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein familyTesting models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signalingbeta-catenin destruction complex: insights and questions from a structural perspectiveThe β-catenin destruction complexThe postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivoHuman APC sequesters β-catenin even in the absence of GSK-3β in a Drosophila modelProtein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell linesdifferent Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coliNuclear APCStructural basis for the recognition of Asef by adenomatous polyposis coli.Complete functional segregation of planarian beta-catenin-1 and -2 in mediating Wnt signaling and cell adhesion.Immunopurification of adenomatous polyposis coli (APC) proteins.Signaling from the adherens junction.The evolutionary origin of epithelial cell-cell adhesion mechanismsWnt signalling pathway parameters for mammalian cellsCortical localization of APC2 plays a role in actin organization but not in Wnt signaling in DrosophilaModeling the effect of APC truncation on destruction complex function in colorectal cancer cellsDeconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signalingPurification, crystallization and preliminary X-ray diffraction studies of the β-catenin homolog HMP-2 from Caenorhabditis elegans.Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and ArmadilloThe two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling.Molecular plasticity of beta-catenin: new insights from single-molecule measurements and MD simulation.Analysis of bacteria from intestinal tract of FAP patients for the presence of APC-like sequencesStructures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners.Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells.PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation.The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.The way Wnt works: components and mechanism.The generation of phosphoserine stretches in phosphoproteins: mechanism and significance.Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.CK1 in Developmental Signaling: Hedgehog and Wnt.Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1.
P2860
Q21245770-EBE38B63-067F-4C09-9AD9-DB4D266F5BEEQ21559553-7B8DF787-06FA-46FF-AB5A-0EE1B17D5B4EQ24295448-4F0D57AA-7D8E-4F70-B66A-772264DEFF88Q24653563-97FFBFED-39B4-4A96-8B8C-06661C89E4D8Q27015094-31534782-483D-44A8-8610-9078D8AD710BQ27650057-86AD7465-CB32-4571-8883-34BE2144C735Q27665877-A7B06460-3599-494A-838F-7BC9EC973886Q27685309-55621B75-7846-4F03-AAC3-3B4A68ED4278Q28242004-E0280574-6AB3-48A1-9C80-F7D0C59F655AQ28276987-F5B8D1E0-EF51-4287-B036-05FBAF9C6F80Q28279593-8349A144-384E-4363-A6A8-C6C04773E760Q28290853-37E380DE-2192-4DCB-984F-711CEEEDAD21Q28315010-559FE33B-8B6B-4373-B6E5-EC464391DF48Q28487798-6486E94E-4FF0-44F1-B8B3-1380AE5FA13CQ28537734-C115DA27-302B-4A8B-A9D5-FDB9D7BFDFD1Q28642503-2EFFB51D-AB8C-4E78-AF38-FD26A83B3CD5Q30010267-0164F367-D2BA-4617-BBBC-30293D509A9AQ30495735-CE0F8CB6-B4E3-4154-8996-15342719BE28Q33588363-D5D9E1D7-7DBC-4CA1-997B-78C411BE0E0FQ33652999-DF170056-3969-4AC7-8CC7-32A2B7B9273BQ33987571-C782CEA3-3E00-4122-9B03-3678D1C4288EQ34171489-A7EDD8D5-566D-48D0-B409-457776E47D1CQ34808737-CFE0AE92-473E-4F49-91CD-EACBD36C3E29Q35004421-4890DF54-BA2F-4963-8DD2-193AA585CA8BQ35011212-72A248C5-9AE2-46A8-9B79-792AA94E66FFQ35167511-1C02B2CC-3A13-4975-8D05-3E6CD6E3B555Q35690072-2F8DB85B-AF3D-425C-BFD1-44C89AC1C7A6Q35810766-1F5BA36A-AE21-4D70-8BAA-F0E9B4D39DC7Q36337058-DDF2D5E6-2DD1-4E16-82D6-9F1471331E68Q36393520-608666E1-3562-4BF3-812C-F046A90840E9Q36577279-EDDDBFDA-985C-4FFA-8C9E-DA0BC8795027Q36882749-D61FCFD7-CC38-439C-9698-EF63AC37F84EQ37343986-A68588DB-DC46-4894-B745-5B0294893880Q37371627-592B42A0-C23A-4993-B30F-1BD4A393D85AQ37459971-77119518-ABE1-4EE7-93E0-0E66268632A9Q38068918-DFCF3D53-1E17-42C2-B9BF-0D48A0A1AB2FQ38554532-8F40CE5E-EF0E-4D36-A089-72FEC0FA6A39Q38807957-72AD0A9E-1BCA-40F6-98FA-F03D0BAFED46Q39150566-45FFC5CF-A21C-4E1D-BD95-92A93E48DE1BQ39209419-84289FA2-621D-46FA-81D5-85F28AAF14EF
P2860
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structure of a beta-ca ...... hosphorylation in APC function
@ast
Crystal structure of a beta-ca ...... hosphorylation in APC function
@en
Crystal structure of a beta-ca ...... hosphorylation in APC function
@en-gb
Crystal structure of a beta-ca ...... hosphorylation in APC function
@nl
type
label
Crystal structure of a beta-ca ...... hosphorylation in APC function
@ast
Crystal structure of a beta-ca ...... hosphorylation in APC function
@en
Crystal structure of a beta-ca ...... hosphorylation in APC function
@en-gb
Crystal structure of a beta-ca ...... hosphorylation in APC function
@nl
prefLabel
Crystal structure of a beta-ca ...... hosphorylation in APC function
@ast
Crystal structure of a beta-ca ...... hosphorylation in APC function
@en
Crystal structure of a beta-ca ...... hosphorylation in APC function
@en-gb
Crystal structure of a beta-ca ...... hosphorylation in APC function
@nl
P2093
P1433
P1476
Crystal structure of a beta-ca ...... hosphorylation in APC function
@en
P2093
David Kimelman
Isolde Le Trong
Ronald Stenkamp
Thomas R Hinds
P304
P356
10.1016/J.MOLCEL.2004.08.001
P407
P577
2004-08-27T00:00:00Z