Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
about
ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetlesThe deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.OTUB1 modulates c-IAP1 stability to regulate signalling pathwaysDUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workThe Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiaeRoles of protein ubiquitination and degradation kinetics in biological oscillationsThe role of Cdc25A in the regulation of cell proliferation and apoptosisIdentification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancerThe DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistanceCDC25A(Q110del): a novel cell division cycle 25A isoform aberrantly expressed in non-small cell lung cancerGene expression analysis of PTEN positive glioblastoma stem cells identifies DUB3 and Wee1 modulation in a cell differentiation modelCell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.Ubp8 and SAGA regulate Snf1 AMP kinase activity.Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells.Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancerGenomic analysis of circulating cell-free DNA infers breast cancer dormancy.Deubiquitinases in cancer.K63-linked ubiquitination in kinase activation and cancer.The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferationDUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT ProteinsThe Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33.The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.Protein turnover during in vitro tissue engineering.Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer.The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeuticsCDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation.Ubiquitin-specific proteases as cancer drug targets.Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications.Cell death and deubiquitinases: perspectives in cancer.Ubiquitination in disease pathogenesis and treatment.Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme.DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.Dub3 controls DNA damage signalling by direct deubiquitination of H2AX.The role of deubiquitinases in breast cancer.DNA released by leukemic cells contributes to the disruption of the bone marrow microenvironment.
P2860
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P2860
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@ast
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@en
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@en-gb
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@nl
type
label
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@ast
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@en
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@en-gb
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@nl
prefLabel
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@ast
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@en
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@en-gb
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@nl
P2093
P3181
P356
P1433
P1476
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
@en
P2093
Anwesha Dey
Dorothy M French
Karen M O'Rourke
Laszlo Komuves
Meredith Sagolla
Vishva M Dixit
Yaron Pereg
P2888
P3181
P356
10.1038/NCB2041
P407
P577
2010-04-01T00:00:00Z
P5875
P6179
1024854295