Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy
about
A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membraneMammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processesNesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarizationThe molecular basis of emerin-emerin and emerin-BAF interactionsMuscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organizationO-Linked β-N-acetylglucosamine (O-GlcNAc) regulates emerin binding to barrier to autointegration factor (BAF) in a chromatin- and lamin B-enriched "niche".Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.Lamin-binding ProteinsStabilization of the spectrin-like domains of nesprin-1α by the evolutionarily conserved "adaptive" domain.Nuclear lamins.Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication.LINC complexes in health and disease.Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteinsStructural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling.Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.Making the LINC: SUN and KASH protein interactions.The cellular mastermind(?)-mechanotransduction and the nucleus.Moving and positioning the nucleus in skeletal muscle - one step at a timeLamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy.A nuclear-envelope bridge positions nuclei and moves chromosomesNuclear positioning in muscle development and disease.Role of A-type lamins in signaling, transcription, and chromatin organization.Nuclear damages and oxidative stress: new perspectives for laminopathies.Nesprins: from the nuclear envelope and beyond.Protein interactions at the higher plant nuclear envelope: evidence for a linker of nucleoskeleton and cytoskeleton complex.Nuclear Mechanics and Stem Cell Differentiation.N-terminal nesprin-2 variants regulate β-catenin signallingControl of nuclear organization by F-actin binding proteins.Mechanotransduction and nuclear function.Nesprin-1 role in DNA damage responseNovel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation.Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases.Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins.
P2860
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P2860
Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@ast
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@en
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@nl
type
label
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@ast
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@en
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@nl
prefLabel
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@ast
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@en
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@nl
P2093
P1476
Distinct functional domains in ...... ry-Dreifuss muscular dystrophy
@en
P2093
James Hunt
John D Davies
Juliet A Ellis
Lindsay J Emerson
Matthew A Wheeler
P304
P356
10.1016/J.YEXCR.2007.03.025
P407
P577
2007-03-30T00:00:00Z