Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme
about
The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseasesThe bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasisMolecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductaseAldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugatesCrystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and CatalysisStructure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)Conversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERINGTissue distribution, ontogeny, and chemical induction of aldo-keto reductases in miceComparative anatomy of the aldo-keto reductase superfamilyShared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent strokeLow levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms.Cell- and gene-specific regulation of primary target genes by the androgen receptor.Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency.New frontiers in androgen biosynthesis and metabolism.Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesisRole of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolismDelta 4-3-oxosteroid 5 beta-reductase deficiency: failure of ursodeoxycholic acid treatment and response to chenodeoxycholic acid plus cholic acidMechanisms of liver injury relevant to pediatric hepatology.Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms.Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)The aldo-keto reductases (AKRs): Overview.Genetics of familial intrahepatic cholestasis syndromes.Aldo-keto reductase (AKR) superfamily: genomics and annotation.Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy.Promiscuity and diversity in 3-ketosteroid reductases.Differential Feedback Regulation of Δ4-3-Oxosteroid 5β-Reductase Expression by Bile Acids.Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature.Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathwayMetabolic dysfunction in female mice with disruption of 5α-reductase 15β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1).Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function.Active site prediction for comparative model structures with thematics.Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization.Changes in liver proteome expression of Senegalese sole (Solea senegalensis) in response to repeated handling stress.Women with acute intermittent porphyria have a defect in 5α-steroid production during the menstrual cycle.Dysregulation of Δ4-3-oxosteroid 5β-reductase in diabetic patients: Implications and mechanisms.4-cholesten-7alpha; 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha; 12alpha-diol-3-one4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one4-cholesten-7alpha;12alpha;24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha;12alpha;24(S)-triol-3-one
P2860
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P2860
Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@ast
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@en
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@en-gb
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@nl
type
label
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@ast
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@en
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@en-gb
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@nl
prefLabel
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@ast
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@en
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@en-gb
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@nl
P2093
P2860
P3181
P1433
P1476
Cloning and expression of cDNA ...... ficity of the expressed enzyme
@en
P2093
G Eggertsen
T Setoguchi
Y Setoguchi
P2860
P304
P3181
P356
10.1111/J.1432-1033.1994.TB19947.X
P407
P577
1994-01-15T00:00:00Z