The dystonia-associated protein torsinA modulates synaptic vesicle recycling
about
Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinADopamine release in the basal gangliaThe early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitroCSN complex controls the stability of selected synaptic proteins via a torsinA-dependent processPrintor, a novel torsinA-interacting protein implicated in dystonia pathogenesisDevelopmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystoniaBotulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neuronsTorsins: not your typical AAA+ ATPasesImpaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia.A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1).The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice.Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast.Current Gaps in the Understanding of the Subcellular Distribution of Exogenous and Endogenous Protein TorsinA.A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding.The zebrafish homologue of the human DYT1 dystonia gene is widely expressed in CNS neurons but non-essential for early motor system development4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunctionGenetic and clinical features of primary torsion dystonia.Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry.Decreased dopamine receptor 1 activity and impaired motor-skill transfer in Dyt1 ΔGAG heterozygous knock-in mice.Pre-synaptic release deficits in a DYT1 dystonia mouse model.Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice.Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling.Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits.TorsinA participates in endoplasmic reticulum-associated degradationRecent advances in the molecular pathogenesis of dystonia-plus syndromes and heredodegenerative dystonias.Identifying the genetic components underlying the pathophysiology of movement disorders.Glial elements contribute to stress-induced torsinA expression in the CNS and peripheral nervous systemSnapin associates with late endocytic compartments and interacts with late endosomal SNAREsEngineering animal models of dystoniaInteraction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion.Deep brain stimulation for myoclonus-dystonia syndrome with double mutations in DYT1 and DYT11.Primary dystonia: molecules and mechanisms.Molecular pathways in dystonia.Milestones in dystonia.Emerging common molecular pathways for primary dystonia.Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE.
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P2860
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@ast
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@en
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@en-gb
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@nl
type
label
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@ast
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@en
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@en-gb
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@nl
prefLabel
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@ast
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@en
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@en-gb
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@nl
P2093
P2860
P921
P356
P1476
The dystonia-associated protein torsinA modulates synaptic vesicle recycling
@en
P2093
Alessandra Granata
Lucy M Collinson
Rose Watson
Thomas T Warner
P2860
P304
P356
10.1074/JBC.M704097200
P407
P577
2008-03-21T00:00:00Z