Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line
about
The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNASUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosisNovel insights into mitotic chromosome condensationDual role of topoisomerase II in centromere resolution and aurora B activityCentromere-associated topoisomerase activity in bloodstream form Trypanosoma bruceiCoordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance.Topoisomerase IIalpha maintains genomic stability through decatenation G(2) checkpoint signalingEffects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells.Quantitative analysis of chromosome condensation in fission yeast.A novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation.Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.Mitotic catenation is monitored and resolved by a PKCε-regulated pathwayPurification of GidA protein, a novel topoisomerase II inhibitor produced by Streptomyces flavoviridis.Stringent and reproducible tetracycline-regulated transgene expression by site-specific insertion at chromosomal loci with pre-characterised induction characteristics.Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogueTopoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.Mitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements.Doxorubicin, DNA torsion, and chromatin dynamics.Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle.The dynamics of DNA topoisomerase IIalpha in living cellsThe analysis of mutant alleles of different strength reveals multiple functions of topoisomerase 2 in regulation of Drosophila chromosome structure.Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both topoisomerase II isoforms.Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage.Depletion of topoisomerase IIalpha leads to shortening of the metaphase interkinetochore distance and abnormal persistence of PICH-coated anaphase threads.Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes.Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation.MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.Topoisomerase IIα in chromosome instability and personalized cancer therapy.Epstein-Barr virus BGLF4 kinase induces premature chromosome condensation through activation of condensin and topoisomerase II.Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state.Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.BAF complexes facilitate decatenation of DNA by topoisomerase IIαPackaging the genome: the structure of mitotic chromosomesSUMO modification of DNA topoisomerase II: trying to get a CENse of it allTopoisomerase II beta interacts with cohesin and CTCF at topological domain bordersTopoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish.DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.DNA topoisomerase II and its growing repertoire of biological functions.
P2860
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P2860
Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Construction, characterization ...... IIalpha mutant human cell line
@ast
Construction, characterization ...... IIalpha mutant human cell line
@en
Construction, characterization ...... IIalpha mutant human cell line
@en-gb
Construction, characterization ...... IIalpha mutant human cell line
@nl
type
label
Construction, characterization ...... IIalpha mutant human cell line
@ast
Construction, characterization ...... IIalpha mutant human cell line
@en
Construction, characterization ...... IIalpha mutant human cell line
@en-gb
Construction, characterization ...... IIalpha mutant human cell line
@nl
prefLabel
Construction, characterization ...... IIalpha mutant human cell line
@ast
Construction, characterization ...... IIalpha mutant human cell line
@en
Construction, characterization ...... IIalpha mutant human cell line
@en-gb
Construction, characterization ...... IIalpha mutant human cell line
@nl
P2860
P921
P3181
P356
P1476
Construction, characterization ...... IIalpha mutant human cell line
@en
P2093
Adam J Carpenter
Andrew C G Porter
P2860
P304
P3181
P356
10.1091/MBC.E04-08-0732
P407
P577
2004-12-01T00:00:00Z