The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment
about
Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosisZW10 links mitotic checkpoint signaling to the structural kinetochore.The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death.A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tensionArchitecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochoreHuman NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachmentA conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1Proteome analysis of the human mitotic spindleHistone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment.Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint controlHec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.Linking kinetochore-microtubule binding to the spindle checkpointThe kinetochore interaction network (KIN) of ascomycetesStructural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior.Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.CENP-T provides a structural platform for outer kinetochore assemblyThe fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle associationMolecular organization of the Ndc80 complex, an essential kinetochore component.The unconventional kinetoplastid kinetochore: from discovery toward functional understandingMolecular analysis of core kinetochore composition and assembly in Drosophila melanogasterMechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores.The Toxoplasma gondii kinetochore is required for centrosome association with the centrocone (spindle pole)Dynamic Phosphorylation of NudC by Aurora B in CytokinesismiR-183 Inhibits UV-Induced DNA Damage Repair in Human Trabecular Meshwork Cells by Targeting of KIAA0101CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.Multimodal microtubule binding by the Ndc80 kinetochore complex.Looping in on Ndc80 - how does a protein loop at the kinetochore control chromosome segregation?The Ndc80 complex: integrating the kinetochore's many movements.Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1).The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore.Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin.Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly.Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis.The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosisTranscriptome analysis reveals potential mechanisms underlying differential heart development in fast- and slow-growing broilers under heat stress.SPC24 is critical for anaplastic thyroid cancer progression.Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4.
P2860
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P2860
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment
description
2004 nî lūn-bûn
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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
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name
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@ast
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@en
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@en-gb
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@nl
type
label
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@ast
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@en
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@en-gb
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@nl
prefLabel
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@ast
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@en
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@en-gb
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@nl
P2093
P50
P3181
P1433
P1476
The vertebrate Ndc80 complex c ...... tochore-microtubule attachment
@en
P2093
Cortney A Kestner
Donald F Hunt
Gregory A Barrett-Wilt
Mark L McCleland
P3181
P356
10.1016/J.CUB.2003.12.058
P407
P577
2004-01-20T00:00:00Z